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Stereotactic heart ablative radiotherapy (SHARP): a prospective multicentric phase II trial

Cardiac tumors are exceedingly rare with metastatic involvement representing the most frequent form of malignancy within the heart. In patients presenting with inoperable primary or recurrent malignant cardiac sarcomas or cardiac/epicardial/pericardial metastases, stereotactic body radiotherapy (SBR...

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Main Authors: Gaasch, Aurélie Virginie (Author) , Marschner, Sebastian N. (Author) , Hoegen-Saßmannshausen, Philipp (Author) , Sandrini, Elisabetta (Author) , Hörner-Rieber, Juliane (Author) , Andratschke, Nicolaus (Author) , Balermpas, Panagiotis (Author) , Boldrini, Luca (Author) , Romano, Angela (Author) , Reiner, Michael (Author) , Niyazi, Maximilian (Author) , Lindner, Lars (Author) , Weckbach, Ludwig (Author) , Fink, Nicola (Author) , Hagl, Christian (Author) , Belka, Claus (Author) , Corradini, Stefanie (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: Strahlentherapie und Onkologie
Year: 2026, Volume: 202, Issue: 7, Pages: 744-750
ISSN:1439-099X
DOI:10.1007/s00066-026-02504-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00066-026-02504-5
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Author Notes:Aurélie Gaasch, Sebastian N. Marschner, Philipp Hoegen-Saßmannshausen, Elisabetta Sandrini, Juliane Hörner-Rieber, Nicolaus Andratschke, Panagiotis Balermpas, Luca Boldrini, Angela Romano, Michael Reiner, Maximilian Niyazi, Lars Lindner, Ludwig Weckbach, Nicola Fink, Christian Hagl, Claus Belka, Stefanie Corradini
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Summary:Cardiac tumors are exceedingly rare with metastatic involvement representing the most frequent form of malignancy within the heart. In patients presenting with inoperable primary or recurrent malignant cardiac sarcomas or cardiac/epicardial/pericardial metastases, stereotactic body radiotherapy (SBRT) serves as an alternative local treatment to surgery or may, in some cases, constitute the sole viable local treatment modality. To date, there are only case reports or small retrospective studies assessing SBRT dose and toxicity for cardiac SBRT. The goal of this prospective multicentric observational study is to systematically evaluate the feasibility, toxicity and outcome of magnetic resonance-guided stereotactic body radiation therapy (MRgSBRT) in the management of primary and secondary cardiac malignancies.
Item Description:Online veröffentlicht: 30. Januar 2026
Gesehen am 27.05.2026
Physical Description:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-026-02504-5

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