Image de couverture de livre

Urinary metabolomics predict acute kidney injury in very-low-birth-weight infants with patent ductus arteriosus

Very preterm infants with immature kidneys exhibit high vulnerability to acute kidney injury (AKI). While AKI is associated with adverse outcomes, serum-creatinine-based diagnostics prove unreliable in early risk assessment of kidney damage. This pilot study investigated 1H-NMR spectroscopy-based me...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Niesert, Moritz (Auteur) , Cannet, Claire (Auteur) , Fichtner, Alexander (Auteur) , Hoffmann, Georg F. (Auteur) , Okun, Jürgen G. (Auteur) , Pituk, Dóra (Auteur) , Gille, Christian (Auteur) , Pöschl, Johannes (Auteur) , Waldherr, Sina (Auteur) , Ziegler, Andreas (Auteur) , Westhoff, Jens (Auteur)
Format: Article (Journal)
Langue:anglais
Publié: 5 March 2026
In: Biomolecules
Year: 2026, Volume: 16, Numéro: 3, Pages: 1-16
ISSN:2218-273X
DOI:10.3390/biom16030391
Accès en ligne:Resolving-System, kostenfrei, Volltext: https://doi.org/10.3390/biom16030391
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2218-273X/16/3/391
Accéder au texte intégral
Notes sur l'auteur:Moritz Niesert, Claire Cannet, Alexander Fichtner, Georg F. Hoffmann, Jürgen G. Okun, Dóra Pituk, Christian Gille, Johannes Pöschl, Sina Waldherr, Andreas Ziegler and Jens H. Westhoff
Description
Résumé:Very preterm infants with immature kidneys exhibit high vulnerability to acute kidney injury (AKI). While AKI is associated with adverse outcomes, serum-creatinine-based diagnostics prove unreliable in early risk assessment of kidney damage. This pilot study investigated 1H-NMR spectroscopy-based metabolomics for the identification of very-low-birth-weight (VLBW < 1500 g) infants at risk of AKI before and during indomethacin treatment for patent ductus arteriosus (PDA). Longitudinal urine samples (0 h, 12 h, 36 h, 84 h, 120 h, 14 d, 28 d) from 12 VLBW infants receiving indomethacin for hemodynamically significant PDA were analyzed by 1H-NMR spectroscopy. In total, 150 urinary metabolites were annotated and single-metabolite and multivariate analyses were performed. At 36 h after treatment initiation, three patients (25%) developed AKI (KDIGO criteria). Principal component analysis (PCA) revealed significant differences in urinary metabolic profiles between the AKI and non-AKI groups 12 h after indomethacin initiation. Before treatment, five metabolites were significantly lower in the AKI group: adenine, creatine, dimethylglycine, 1-methylnicotinamide, and methylmalonic acid. Urinary creatine/creatinine (AUC 0.97) and 1-methylnicotinamide/creatinine (AUC 0.93) exhibited promising prognostic accuracy for the prediction of AKI. 1-methylnicotinamide/creatinine concentrations remained persistently reduced during the study. In conclusion, urinary metabolomics, particularly creatine and 1-methylnicotinamide levels, may serve as valuable non-invasive biomarkers for identifying VLBW infants at risk of AKI.
Description:Gesehen am 02.06.2026
Description matérielle:Online Resource
ISSN:2218-273X
DOI:10.3390/biom16030391

Documents similaires