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Objective performance goals after open and endovascular intervention for critical limb ischaemia: a systematic review with a meta-analysis

Background: Whether current real-world treatment of critical limb ischemia with lower extremity bypass (LEB) or infrainguinal endovascular intervention (IEI) meets the Society for Vascular Surgery objective performance goals (OPG) was investigated. Materials and methods: Literature search in PubMed,...

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Bibliographic Details
Main Authors: Debus, Eike Sebastian (Author) , Epple, Jasmin (Author) , Reese, Carl-Leon (Author) , Golbach, Rejane (Author) , Grundmann, Reinhart T. (Author)
Format: Article (Journal)
Language:English
Published: April 22, 2026
In: Vasa
Year: 2026, Pages: 1-7
ISSN:1664-2872
Online Access:Verlag, kostenfrei, Volltext: https://econtent.hogrefe.com/doi/10.1024/0301-1526/a001285
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Author Notes:Eike Sebastian Debus, Jasmin Epple, Carl-Leon Reese, Rejane Golbach, and Reinhart T. Grundmann
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Summary:Background: Whether current real-world treatment of critical limb ischemia with lower extremity bypass (LEB) or infrainguinal endovascular intervention (IEI) meets the Society for Vascular Surgery objective performance goals (OPG) was investigated. Materials and methods: Literature search in PubMed, studies from 2010 to March 2021. A total of 35,981 endovascular interventions were reported in 82 publications and 26,707 open procedures in 49 publications. Results: Perioperative major adverse limb events was 8% (OPG) versus 9% for IEI and 10% for LEB (no significant differences). Perioperative major adverse cardiovascular events was significantly better with IEI (4%; p < .001) and LEB (6%; p = .018) than the OPG (8%). After 1 year, amputation-free survival (AFS) was 76.5% (OPG), compared to 71% with IEI (p = .932) and 77% with LEB (p = .006) and patient survival was 85.7% (OPG) compared to 84% (LEB; p = .006) and 78% (IEI; p = .102). 5-year survival was 51% with LEB and 45% with IEI (p = .320), and AFS was 44% with LEB and 46% with IEI (p = .802). 5-year OPGs were not reported. Conclusions: In the studies analysed, the results after IEI and LEB largely corresponded to the OPGs. 5-year outcomes after LEB and IEI did not differ significantly.
Item Description:Online veröffentlicht: 22. April 2026
Gesehen am 09.06.2026
Physical Description:Online Resource
ISSN:1664-2872

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