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Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction

The majority of clinical studies investigating patients with heart failure and a reduced ejection fraction (HFrEF) exclusively included patients with symptomatic heart failure. There is a paucity of information concerning the clinical characteristics, progression to symptomatic heart failure, heart...

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Main Authors: Müller-Kozarez, Irina (Author) , Sandek, Anja (Author) , Edelmann, Frank (Author) , Gertler, Christoph (Author) , Placzek, Marius (Author) , Friede, Tim (Author) , Licka, Manuela (Author) , Rieth, Andreas (Author) , Schunkert, Heribert (Author) , Akın, Ibrahim (Author) , Arnold, Natalie (Author) , Störk, Stefan (Author) , Feuerstein, Anna (Author) , Herrmann-Lingen, Christoph (Author) , Hasenfuß, Gerd (Author) , Wachter, Rolf (Author)
Format: Article (Journal)
Language:English
Published: 21 January 2026
In: ESC heart failure
Year: 2026, Volume: 13, Issue: 1, Pages: 1-10
ISSN:2055-5822
DOI:10.1093/eschf/xvag012
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/eschf/xvag012
Verlag, kostenfrei, Volltext: https://academic.oup.com/eschf/article/13/1/xvag012/8435259?login=true
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Author Notes:Irina Müller-Kozarez, Anja Sandek, Frank Edelmann, Christoph Gertler, Marius Placzek, Tim Friede, Manuela Licka, Andreas Rieth, Heribert Schunkert, Ibrahim Akin, Natalie Arnold, Stefan Störk, Anna Feuerstein, Christoph Herrmann-Lingen, Gerd Hasenfuß, Rolf Wachter, and TransitionCHF consortium
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Summary:The majority of clinical studies investigating patients with heart failure and a reduced ejection fraction (HFrEF) exclusively included patients with symptomatic heart failure. There is a paucity of information concerning the clinical characteristics, progression to symptomatic heart failure, heart failure hospitalization rates and survival in patients with asymptomatic systolic left ventricular dysfunction (ASLVD). We address this knowledge gap by describing the baseline characteristics of participants in the prospective observational TransitionCHF study of patients with reduced left ventricular Function in New York Heart Association (NYHA) functional Class I and comparing them to those of other recent trials in HFrEF.In total, 1005 individuals with ASLVD NYHA I with an ejection fraction ≤ 40% were recruited. Patient characteristics were compared with other studies involving patients with symptomatic heart failure. Multivariable linear regression and Pearson coefficients were used to determine the association between quality of life, mental health, markers of organ function, N-terminal prohormone of brain natriuretic peptide (NT-proBNP) plasma levels, and exercise performance.The mean age of participants was 60 ± 14 years and 18% were women. The mean ejection fraction was 36% and the mean left ventricular end-diastolic diameter was 59 mm. When compared with studies involving patients with symptomatic heart failure, the age was ≈ 5 years younger and the frequency of comorbidities was lower. The Short Form Health Survey-36 physical functioning score was moderately correlated with the Maastricht Vital Exhaustion Questionnaire (MQ; r = −0.44 and weakly with 6-min walking distance (r = 0.32), peak VO2 at ergospirometry (r = 0.28), and Heart Focus Anxiety (HAF17; r = −0.34). NT-proBNP levels showed a weak association with peak VO2 (r = −0.29) and the 6-min walk distance (r = −0.21).Patients included in the TransitionCHF study are younger and suffer from fewer comorbidities as compared with symptomatic heart failure patients. Associations between NT-proBNP levels and markers of exercise performance were weak.
Item Description:Gesehen am 09.06.2026
Physical Description:Online Resource
ISSN:2055-5822
DOI:10.1093/eschf/xvag012

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