Image de couverture de livre

EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

Epstein-Barr virus (EBV) is involved in causing and probably also in perpetuating multiple sclerosis (MS). Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wang, Jian (Auteur) , Qiu, Yuhan (Auteur) , Marti, Zoe (Auteur) , Li, Fengqi (Auteur) , Wacker, Marcel (Auteur) , Oldrati, Pietro (Auteur) , Mühlenbruch, Lena (Auteur) , Jin, Linlin (Auteur) , Zhang, Hongxia (Auteur) , Xu, Wen (Auteur) , Li, Tingting (Auteur) , Roschitzki, Bernd (Auteur) , Faigle, Wolfgang (Auteur) , Liu, Yingjun (Auteur) , Nguyen, Julie T. (Auteur) , Lee, Jar-How (Auteur) , Haunerdinger, Veronika (Auteur) , Hauri-Hohl, Mathias (Auteur) , Momburg, Frank (Auteur) , Bauer, Jens (Auteur) , Rammensee, Hans-Georg (Auteur) , Sospedra, Mireia (Auteur) , Magliozzi, Roberta (Auteur) , Reynolds, Richard (Auteur) , Walz, Juliane (Auteur) , Martin, Roland (Auteur)
Format: Article (Journal)
Langue:anglais
Publié: 22 January 2026
In: Cell
Year: 2026, Volume: 189, Numéro: 2, Pages: 569-584
ISSN:1097-4172
DOI:10.1016/j.cell.2025.12.046
Accès en ligne:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.cell.2025.12.046
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867425014953
Accéder au texte intégral
Notes sur l'auteur:Jian Wang, Yuhan Qiu, Zoe Marti, Fengqi Li, Marcel Wacker, Pietro Oldrati, Lena Mühlenbruch, Linlin Jin, Hongxia Zhang, Wen Xu, Tingting Li, Bernd Roschitzki, Wolfgang Faigle, Yingjun Liu, Julie T. Nguyen, Jar-How Lee, Veronika Haunerdinger, Mathias Hauri-Hohl, Frank Momburg, Jens Bauer, Hans-Georg Rammensee, Mireia Sospedra, Roberta Magliozzi, Richard Reynolds, Juliane Walz, and Roland Martin
Description
Résumé:Epstein-Barr virus (EBV) is involved in causing and probably also in perpetuating multiple sclerosis (MS). Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we report that EBV reprograms the transcriptome and immunopeptidome presented on the MS-associated human leukocyte antigen (HLA)-DR15 molecules of infected B cells. Identical myelin basic protein (MBP) peptides were found to be presented on both EBV-infected B cells and MS brain tissue but not primary B cells and thymic tissue. Peripheral memory and cerebrospinal fluid (CSF)-derived CD4+ T cells of HLA-DR15+ MS patients responded to MBP peptides, MBP(78-90) and/or MBP(83-90), and T cell clones raised with these peptides recognized all MBP peptides ending at amino acid MBP90 in MS brain tissue. Our study provides a new mechanistic link for how the environmental and genetic risk factors, EBV infection and HLA-DR15 haplotype, may contribute jointly to MS.
Description:Mit graphical abstract
Gesehen am 12.06.2026
Description matérielle:Online Resource
ISSN:1097-4172
DOI:10.1016/j.cell.2025.12.046

Documents similaires