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A brain-wide atlas of astrocytic oxytocin receptors reveals a glial basis for nucleus accumbens modulation of affiliative behavior

Until recently, it was widely assumed that oxytocin signaling occurred exclusively through the activation of neuronal oxytocin receptors, with neurons being the primary targets of released oxytocin. However, this view was challenged by the discovery of functional oxytocin receptors in central amygda...

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Autori principali: Denis, Clémence (Autore) , Stojilkovic, Stefan (Autore) , Wang, Kai-Yi (Autore) , Márquez, Cristina (Autore) , Kleinwächter, Annabel C. (Autore) , Baudon, Angel (Autore) , Podpecan, Yuval (Autore) , Ces, Aurélia (Autore) , Kremer, Mélanie (Autore) , Arnoux, Isabelle (Autore) , Rouach, Nathalie (Autore) , Jemima Helen (Autore) , Trender, Sophie (Autore) , Wallkum, Andreas (Autore) , Wunsch, Selina (Autore) , Schommer, Franziska (Autore) , Wimmer, Moritz Claudius (Autore) , Schubert, Tim (Autore) , Franke, Felix (Autore) , Muhammad, Jabir Aliyu (Autore) , Eisemann, Eva M. (Autore) , Possa Paranhos, Ingrid (Autore) , Baumann, Cassandra (Autore) , Derrien, Pierre-Alexis (Autore) , Krabichler, Quirin (Autore) , Garcia, Cosmo (Autore) , Fröhlich, Henning (Autore) , Kirchner, Matthew K. (Autore) , Grinevich, Valéry (Autore) , Darbon, Pascal (Autore) , Stern, Javier E. (Autore) , Althammer, Ferdinand (Autore) , Charlet, Alexandre (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 2026
In: Advanced science
Year: 2026, Pages: 1-19
ISSN:2198-3844
DOI:10.1002/advs.202518450
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/advs.202518450
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202518450
Testo
Note sull'autore:Clémence Denis, Stefan Stojilkovic, Kai-Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa-Paranhos, Cassandra Baumann, Pierre-Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet
Descrizione
Riassunto:Until recently, it was widely assumed that oxytocin signaling occurred exclusively through the activation of neuronal oxytocin receptors, with neurons being the primary targets of released oxytocin. However, this view was challenged by the discovery of functional oxytocin receptors in central amygdala astrocytes, which are essential for the proper function of local neuronal microcircuits. Since then, astrocytic oxytocin receptors have been implicated in various aspects of rodent physiology and behavior, yet it remains unclear whether this mechanism is region-specific or widespread across the brain. Here, we provide extensive anatomical data on oxytocin receptor expression in mice and rats, functionally validated through calcium imaging. Based on this mapping and using genetic, calcium imaging and behavioral approaches, we further demonstrate a critical role for oxytocin receptor-expressing astrocytes in the nucleus accumbens in social behavior. In summary, our findings demonstrate that oxytocin receptors are widely expressed in astrocytes across different brain regions. In the nucleus accumbens, these receptors modulate social behavior—an observation with significant implications for the current model of oxytocinergic modulation in the brain.
Descrizione del documento:Erstmals veröffentlicht: 4. Juni 2026
Gesehen am 16.06.2026
Descrizione fisica:Online Resource
ISSN:2198-3844
DOI:10.1002/advs.202518450

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