Cover Image

Psychomotor slowing as a predictor of treatment outcomes in major depressive disorder with acute suicidality: Insights from the OASIS-D study

Psychomotor slowing (PS) is common across mental disorders and has been linked to the clinical course of major depressive disorder (MDD). Prospective evidence as a predictor of treatment outcomes remains limited. We hypothesized that baseline PS severity would be associated with negative treatment o...

Full description

Saved in:
Bibliographic Details
Main Authors: Fritze, Stefan (Author) , Reinhard, Iris (Author) , Nöhles, Viktor B. (Author) , Adam, Till J. (Author) , Bermpohl, Felix (Author) , Schoofs, Nikola (Author) , Bathe-Peters, Rouven (Author) , Hilpert, Nina (Author) , Dafsari, Forugh Salimi (Author) , Falkai, Peter (Author) , Schüle, Cornelius (Author) , Wang, Elena (Author) , Grobe, Henning (Author) , Baum, Clara Lena (Author) , Reif-Leonhard, Christine (Author) , Reif, Andreas (Author) , Schillo, Susanne (Author) , Arshad, Rabia Sana (Author) , Getty, Patricia (Author) , Otte, Christian (Author) , Piber, Dominique (Author) , Graumann, Livia (Author) , Weyn-Banningh, Sebastian (Author) , Adli, Mazda (Author) , Papenfuß, René (Author) , Bauer, Michael (Author) , Lewitzka, Ute (Author) , Spreer, Maik (Author) , Krug, Clemens Karl (Author) , Rubarth, Kerstin (Author) , Correll, Christoph U. (Author) , Meyer-Lindenberg, Andreas (Author) , Hirjak, Dusan (Author)
Format: Article (Journal)
Language:English
Published: September 2026
In: European neuropsychopharmacology
Year: 2026, Volume: 110, Pages: 1-8
ISSN:1873-7862
DOI:10.1016/j.euroneuro.2026.112878
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.euroneuro.2026.112878
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0924977X26001197
Get full text
Author Notes:Stefan Fritze, Iris Reinhard, Viktor B. Nöhles, Till J. Adam, Felix Bermpohl, Nikola Schoofs, Rouven Bathe-Peters, Nina Hilpert, Forugh Salimi Dafsari, Peter Falkai, Cornelius Schüle, Elena Wang, Henning Grobe, Clara Lena Baum, Christine Reif-Leonhard, Andreas Reif, Susanne Schillo, Rabia Sana Arshad, Patricia Getty, Christian Otte, Dominique Piber, Livia Graumann, Sebastian Weyn-Banningh, Mazda Adli, René Papenfuß, Michael Bauer, Ute Lewitzka, Maik Spreer, Clemens Karl Krug, Kerstin Rubarth, Christoph U. Correll, Andreas Meyer-Lindenberg, Dusan Hirjak
Description
Summary:Psychomotor slowing (PS) is common across mental disorders and has been linked to the clinical course of major depressive disorder (MDD). Prospective evidence as a predictor of treatment outcomes remains limited. We hypothesized that baseline PS severity would be associated with negative treatment outcomes in patients with MDD including the severity of acute suicidality. We analyzed data from a 6-month prospective, multicenter observational study of inpatients with MDD and acute suicidality. Depression (Montgomery-Asberg Depression Rating Scale), suicidality (Sheehan-Suicide Tracking Scale), Personal and Social Performance Scale (PSP), Work Productivity and Activity Impairment (WPAI, item #6) and quality of life (European Quality of Life Group, 5-Dimension) were assessed at baseline (T1), inpatient discharge (T2), and 3-months (T3) and 6-months (T4). Linear mixed models were fitted to examine associations between baseline PS (item #15 of the Quick Inventory of Depressive Symptomatology-Self-Report) and outcomes across timepoints, using Bonferroni correction. Among 235 participants (age = 36.4 ± 13.6 years; women = 57.9%), across all timepoints, baseline PS was significantly associated with greater depression symptom severity (p < 0.001), lower quality of life (p = 0.042), reduced leisure time productivity (p = 0.002), and higher suicidality (p = 0.001). The association of baseline PS with social functioning was negative (p = 0.043). Only for PSP, the association varied over time, i.e., T4 > T1 and T2 > T1. This first longitudinal study of PS in acutely suicidal MDD patients showed that baseline PS predicted a broad range of clinical and functional outcomes over six months. PS may serve as a prognostic marker and help identify distinct clinical trajectories in MDD.
Item Description:Online verfügbar: 19. Mai 2026, Artikelversion: 19. Mai 2026
Gesehen am 17.06.2026
Physical Description:Online Resource
ISSN:1873-7862
DOI:10.1016/j.euroneuro.2026.112878

Similar Items