Clinical and molecular features of resected early onset pancreatic ductal adenocarcinoma: insights from the NCDB and cBioPortal
Background - Pancreatic cancer with early onset is increasing but comparisons with average onset cases have yielded mixed results (EOPC versus AOPC; age <50 versus ≥50). We compared clinicopathologic features, prognosis, and molecular traits of resected EOPC versus AOPC. - Methods - We retrospect...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Article (Journal) |
| Langue: | anglais |
| Publié: |
April 2026
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| In: |
HPB
Year: 2026, Volume: 28, Numéro: 4, Pages: 515-523 |
| ISSN: | 1477-2574 |
| DOI: | 10.1016/j.hpb.2025.12.026 |
| Accès en ligne: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.hpb.2025.12.026 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1365182X25017587 
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| Notes sur l'auteur: | Nabiha A. Mughal, Omar Mahmud, Ingmar F. Rompen, Mansour E. Riachi, Brian D. Kaplan, Daniel B. Hewitt, Greg D. Sacks, Christopher L. Wolfgang & Ammar A. Javed |
| Résumé: | Background - Pancreatic cancer with early onset is increasing but comparisons with average onset cases have yielded mixed results (EOPC versus AOPC; age <50 versus ≥50). We compared clinicopathologic features, prognosis, and molecular traits of resected EOPC versus AOPC. - Methods - We retrospectively included patients with PDAC resected between 2010 and 2017 from The National Cancer Database (NCDB). Clinicopathologic data were compared across EOPC versus AOPC. Kaplan-Meier curves and cox-regression were used to perform survival analysis. Molecular features were compared using data from the cBioPortal. - Results - 24,078 patients with resected PDAC were included, of whom 1698 (7.1 %) had EOPC. Poor prognostic factors, including high grade, advanced T-stage, and lymphovascular invasion, were less prevalent in EOPC (All p < 0.05). Patients with EOPC more frequently received neoadjuvant (28 % vs. 22 %; p < 0.001) and adjuvant chemotherapy (68 % vs. 58 %; p < 0.001) and experienced improved OS (median OS 29.5 vs 25.9 months, p = 0.023; 5-year OS: 26.9 % vs 20.8 %). No differences in the presence of key driver mutations were observed between the two groups but some distinct oncogenic mutations were observed in EOPC. - Conclusion - EOPC and AOPC are clinically similar but some cases of EOPC may harbor divergent molecular changes. These patients may have only marginally improved survival. |
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| Description: | Gesehen am 19.06.2026 |
| Description matérielle: | Online Resource |
| ISSN: | 1477-2574 |
| DOI: | 10.1016/j.hpb.2025.12.026 |