Cover Image

Tumor microenvironment evolution in lung cancer: spatio-temporal dynamics and clinical implications

The treatment of non-small cell lung cancer (NSCLC), a disease known for its aggressiveness and significant global impact, has substantially improved in recent decades. A notable shift from cytotoxic chemotherapy to more personalized approaches, such as targeted therapies and immunotherapies, has le...

Full description

Saved in:
Bibliographic Details
Main Authors: Dizdarević, Selma (Author) , Timofeev, Oleg (Author) , Kazdal, Daniel (Author) , Pullamsetti, Soni Savai (Author) , Sotillo, Rocio (Author) , Loges, Sonja (Author) , Kobold, Sebastian (Author) , Stenzinger, Albrecht (Author) , Stiewe, Thorsten (Author) , Savai, Rajkumar (Author)
Format: Article (Journal)
Language:English
Published: June 2026
In: Seminars in cancer biology
Year: 2026, Volume: 123/124, Pages: 1-26
ISSN:1096-3650
DOI:10.1016/j.semcancer.2026.04.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.semcancer.2026.04.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1044579X26000477
Get full text
Author Notes:Selma Dizdarević, Oleg Timofeev, Daniel Kazdal, Soni Savai Pullamsetti, Rocio Sotillo, Sonja Loges, Sebastian Kobold, Albrecht Stenzinger, Thorsten Stiewe, Rajkumar Savai
Description
Summary:The treatment of non-small cell lung cancer (NSCLC), a disease known for its aggressiveness and significant global impact, has substantially improved in recent decades. A notable shift from cytotoxic chemotherapy to more personalized approaches, such as targeted therapies and immunotherapies, has led to improved outcomes for some patients. However, the emergence of resistance remains a major challenge in clinical practice, highlighting the inherent adaptability of cancer cells. This adaptability extends beyond genetic and epigenetic changes within malignant cells, as the bidirectional crosstalk with the tumor microenvironment (TME) also plays a crucial role. This complex ecosystem, consisting of various cellular components (e.g., fibroblasts, endothelial cells, immune cells), extracellular matrix elements, and soluble factors, significantly influences tumor progression, metastasis, and treatment response. Therefore, a comprehensive understanding of how the TME evolves under the selective pressures of different therapies is essential for developing more durable and effective treatment strategies for NSCLC.
Item Description:Online verfügbar: 9. Mai 2026, Artikelversion: 15. Mai 2026
Gesehen am 25.06.2026
Physical Description:Online Resource
ISSN:1096-3650
DOI:10.1016/j.semcancer.2026.04.003

Similar Items