A serum lncRNA signature determines oncogenic YAP activity in cancer patients: tumor markers and signatures
Biomarkers are typically identified by comparing human samples such as tissues and serum. However, reliable markers for transcriptionally active oncogenes remain elusive due to tumor heterogeneity and confounding signals from non-tumorous cells. We hypothesize that in vitro screening is sufficient t...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 June 2026
|
| In: |
International journal of cancer
Year: 2026, Pages: 1-15 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.70584 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.70584 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.70584 
|
| Author Notes: | Fabian Rose, Nada El-Ekiaby, Lilija Wehling, Sofia Maria Elisabeth Weiler, Jennifer Schmitt, Marcell Tóth, Fabiola Pedrini, Amruta Damle-Vartak, Carsten Sticht, Rossella Pellegrino, Injie Omar Fawzy, Merna Hatem Mohamed Hamad, Mohamed Negm, Dina Omar, Hossam Eldeen Soliman, Gamal Esmat, Thomas Longerich, Thomas Illig, Bruno Christian Köhler, Anna Saborowski, Heike Bantel, Arndt Vogel, Peter Schirmacher, Ahmed Ihab Abdelaziz, Kai Breuhahn |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1978784635 | ||
| 003 | DE-627 | ||
| 005 | 20260729142146.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260716s2026 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.70584 |2 doi | |
| 035 | |a (DE-627)1978784635 | ||
| 035 | |a (DE-599)KXP1978784635 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rose, Fabian |d 1993- |e VerfasserIn |0 (DE-588)1246208636 |0 (DE-627)1778215238 |4 aut | |
| 245 | 1 | 2 | |a A serum lncRNA signature determines oncogenic YAP activity in cancer patients |b tumor markers and signatures |c Fabian Rose, Nada El-Ekiaby, Lilija Wehling, Sofia Maria Elisabeth Weiler, Jennifer Schmitt, Marcell Tóth, Fabiola Pedrini, Amruta Damle-Vartak, Carsten Sticht, Rossella Pellegrino, Injie Omar Fawzy, Merna Hatem Mohamed Hamad, Mohamed Negm, Dina Omar, Hossam Eldeen Soliman, Gamal Esmat, Thomas Longerich, Thomas Illig, Bruno Christian Köhler, Anna Saborowski, Heike Bantel, Arndt Vogel, Peter Schirmacher, Ahmed Ihab Abdelaziz, Kai Breuhahn |
| 264 | 1 | |c 23 June 2026 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.07.2026 | ||
| 520 | |a Biomarkers are typically identified by comparing human samples such as tissues and serum. However, reliable markers for transcriptionally active oncogenes remain elusive due to tumor heterogeneity and confounding signals from non-tumorous cells. We hypothesize that in vitro screening is sufficient to identify a long non-coding RNA (lncRNA) signature that is a specific marker for oncogenic transcriptional regulators. Exemplified for the Hippo pathway effectors, we integrated experimental NGS and cancer patient expression data with bioinformatics approaches to identify a yes-associated protein (YAP)-specific lncRNA signature in hepatocellular carcinoma (HCC) cells. The lncRNAs in this signature include CYTOR, MIR4435-2HG, SNHG1, and SNHG17, which partly promote HCC cell proliferation and control the sensitivity to YAP/TEA domain transcription factor (TEAD)-targeted inhibition. In HCC tissues, the lncRNA signature is associated with increased nuclear enrichment of YAP, the expression of YAP target genes, and poor clinical outcomes in patients. This association was also confirmed in cells and tissues of other malignancies, including lung adenocarcinoma (LUAD). Notably, the lncRNA signature is detectable in the serum of HCC patients and predicts YAP activation in tumor tissues. In summary, the Hippo pathway-associated lncRNA signature provides a readout for oncogenic YAP activity across cancers, suggesting its potential as a pan-cancer biomarker. Our results highlight oncogene-specific lncRNA signatures as valuable tools for diagnostics, therapy selection, and treatment monitoring. | ||
| 650 | 4 | |a adenocarcinoma | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a hepatocellular carcinoma | |
| 650 | 4 | |a liquid biopsy | |
| 650 | 4 | |a TAZ | |
| 700 | 1 | |a El-Ekiaby, Nada |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wehling, Lilija |d 1991- |e VerfasserIn |0 (DE-588)1187675423 |0 (DE-627)1666614491 |4 aut | |
| 700 | 1 | |a Weiler, Sofia Maria Elisabeth |e VerfasserIn |0 (DE-588)1137854960 |0 (DE-627)89512887X |0 (DE-576)49177088X |4 aut | |
| 700 | 1 | |a Schmitt, Jennifer |e VerfasserIn |0 (DE-588)1343726352 |0 (DE-627)1903984343 |4 aut | |
| 700 | 1 | |a Tóth, Marcell |d 1990- |e VerfasserIn |0 (DE-588)1171731361 |0 (DE-627)1040674186 |0 (DE-576)513819568 |4 aut | |
| 700 | 1 | |a Pedrini, Fabiola |e VerfasserIn |0 (DE-588)1343725321 |0 (DE-627)1903984262 |4 aut | |
| 700 | 1 | |a Damle-Vartak, Amruta |d 1985- |e VerfasserIn |0 (DE-588)1169582966 |0 (DE-627)1034689118 |0 (DE-576)512140189 |4 aut | |
| 700 | 1 | |a Sticht, Carsten |d 1972- |e VerfasserIn |0 (DE-588)1020115718 |0 (DE-627)691110077 |0 (DE-576)250042177 |4 aut | |
| 700 | 1 | |a Pellegrino, Rossella |e VerfasserIn |0 (DE-588)1078935327 |0 (DE-627)839825439 |0 (DE-576)45208315X |4 aut | |
| 700 | 1 | |a Fawzy, Injie Omar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hamad, Merna Hatem Mohamed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Negm, Mohamed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Omar, Dina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Soliman, Hossam Eldeen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Esmat, Gamal |e VerfasserIn |4 aut | |
| 700 | 1 | |a Longerich, Thomas |d 1974- |e VerfasserIn |0 (DE-588)128494514 |0 (DE-627)373916124 |0 (DE-576)297178059 |4 aut | |
| 700 | 1 | |a Illig, Thomas |e VerfasserIn |0 (DE-588)1118533682 |0 (DE-627)872007286 |0 (DE-576)479518289 |4 aut | |
| 700 | 1 | |a Köhler, Bruno Christian |d 1985- |e VerfasserIn |0 (DE-588)1018431411 |0 (DE-627)682308536 |0 (DE-576)355770288 |4 aut | |
| 700 | 1 | |a Saborowski, Anna |d 1981- |e VerfasserIn |0 (DE-588)134222571 |0 (DE-627)563029390 |0 (DE-576)30038579X |4 aut | |
| 700 | 1 | |a Bantel, Heike |d 1968- |e VerfasserIn |0 (DE-588)133665720 |0 (DE-627)550182861 |0 (DE-576)175936218 |4 aut | |
| 700 | 1 | |a Vogel, Arndt |d 1971- |e VerfasserIn |0 (DE-588)12366960X |0 (DE-627)082697256 |0 (DE-576)293818622 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Abdelaziz, Ahmed Ihab |d 1971- |e VerfasserIn |0 (DE-588)129525901 |0 (DE-627)471011266 |0 (DE-576)29770561X |4 aut | |
| 700 | 1 | |a Breuhahn, Kai |d 1969- |e VerfasserIn |0 (DE-588)122803329 |0 (DE-627)082164959 |0 (DE-576)293427364 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g (2026), Seite 1-15 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a A serum lncRNA signature determines oncogenic YAP activity in cancer patients tumor markers and signatures |
| 773 | 1 | 8 | |g year:2026 |g pages:1-15 |g extent:15 |a A serum lncRNA signature determines oncogenic YAP activity in cancer patients tumor markers and signatures |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.70584 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.70584 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260716 | ||
| 993 | |a Article | ||
| 994 | |a 2026 | ||
| 998 | |g 122803329 |a Breuhahn, Kai |m 122803329:Breuhahn, Kai |d 910000 |d 912000 |d 50000 |e 910000PB122803329 |e 912000PB122803329 |e 50000PB122803329 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 25 |y j | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 23 | ||
| 998 | |g 1018431411 |a Köhler, Bruno Christian |m 1018431411:Köhler, Bruno Christian |d 910000 |d 910100 |d 50000 |e 910000PK1018431411 |e 910100PK1018431411 |e 50000PK1018431411 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 19 | ||
| 998 | |g 128494514 |a Longerich, Thomas |m 128494514:Longerich, Thomas |d 910000 |d 912000 |e 910000PL128494514 |e 912000PL128494514 |k 0/910000/ |k 1/910000/912000/ |p 17 | ||
| 998 | |g 1020115718 |a Sticht, Carsten |m 1020115718:Sticht, Carsten |d 60000 |d 60200 |d 60210 |e 60000PS1020115718 |e 60200PS1020115718 |e 60210PS1020115718 |k 0/60000/ |k 1/60000/60200/ |k 2/60000/60200/60210/ |p 9 | ||
| 998 | |g 1343725321 |a Pedrini, Fabiola |m 1343725321:Pedrini, Fabiola |d 910000 |d 912000 |d 140000 |e 910000PP1343725321 |e 912000PP1343725321 |e 140000PP1343725321 |k 0/910000/ |k 1/910000/912000/ |k 0/140000/ |p 7 | ||
| 998 | |g 1171731361 |a Tóth, Marcell |m 1171731361:Tóth, Marcell |d 50000 |e 50000PT1171731361 |k 0/50000/ |p 6 | ||
| 998 | |g 1137854960 |a Weiler, Sofia Maria Elisabeth |m 1137854960:Weiler, Sofia Maria Elisabeth |d 910000 |d 912000 |e 910000PW1137854960 |e 912000PW1137854960 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 999 | |a KXP-PPN1978784635 |e 4997938726 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1978784635","name":{"displayForm":["Fabian Rose, Nada El-Ekiaby, Lilija Wehling, Sofia Maria Elisabeth Weiler, Jennifer Schmitt, Marcell Tóth, Fabiola Pedrini, Amruta Damle-Vartak, Carsten Sticht, Rossella Pellegrino, Injie Omar Fawzy, Merna Hatem Mohamed Hamad, Mohamed Negm, Dina Omar, Hossam Eldeen Soliman, Gamal Esmat, Thomas Longerich, Thomas Illig, Bruno Christian Köhler, Anna Saborowski, Heike Bantel, Arndt Vogel, Peter Schirmacher, Ahmed Ihab Abdelaziz, Kai Breuhahn"]},"relHost":[{"titleAlt":[{"title":"Predictive oncology"}],"language":["eng"],"pubHistory":["1.1966 -"],"origin":[{"dateIssuedDisp":"1966-","dateIssuedKey":"1966","publisherPlace":"Bognor Regis","publisher":"Wiley-Liss"}],"physDesc":[{"extent":"Online-Ressource"}],"titleTranslated":[{"translated":"Journal international du cancer"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"display":"International Union against Cancer","role":"isb"}],"disp":"A serum lncRNA signature determines oncogenic YAP activity in cancer patients tumor markers and signaturesInternational journal of cancer","id":{"zdb":["1474822-8"],"issn":["1097-0215"],"eki":["269532781"],"doi":["10.1002/(ISSN)1097-0215"]},"title":[{"title_sort":"International journal of cancer","title":"International journal of cancer","subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer"}],"note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"recId":"269532781","part":{"year":"2026","text":"(2026), Seite 1-15","extent":"15","pages":"1-15"}}],"note":["Gesehen am 16.07.2026"],"physDesc":[{"noteIll":"Illustrationen, Diagramme","extent":"15 S."}],"origin":[{"dateIssuedKey":"2026","dateIssuedDisp":"23 June 2026"}],"id":{"doi":["10.1002/ijc.70584"],"eki":["1978784635"]},"person":[{"family":"Rose","given":"Fabian","role":"aut","display":"Rose, Fabian"},{"family":"El-Ekiaby","given":"Nada","display":"El-Ekiaby, Nada","role":"aut"},{"display":"Wehling, Lilija","role":"aut","family":"Wehling","given":"Lilija"},{"family":"Weiler","given":"Sofia Maria Elisabeth","role":"aut","display":"Weiler, Sofia Maria Elisabeth"},{"display":"Schmitt, Jennifer","role":"aut","given":"Jennifer","family":"Schmitt"},{"role":"aut","display":"Tóth, Marcell","family":"Tóth","given":"Marcell"},{"display":"Pedrini, Fabiola","role":"aut","given":"Fabiola","family":"Pedrini"},{"family":"Damle-Vartak","given":"Amruta","display":"Damle-Vartak, Amruta","role":"aut"},{"given":"Carsten","family":"Sticht","role":"aut","display":"Sticht, Carsten"},{"family":"Pellegrino","given":"Rossella","display":"Pellegrino, Rossella","role":"aut"},{"role":"aut","display":"Fawzy, Injie Omar","given":"Injie Omar","family":"Fawzy"},{"given":"Merna Hatem Mohamed","family":"Hamad","role":"aut","display":"Hamad, Merna Hatem Mohamed"},{"display":"Negm, Mohamed","role":"aut","family":"Negm","given":"Mohamed"},{"family":"Omar","given":"Dina","role":"aut","display":"Omar, Dina"},{"role":"aut","display":"Soliman, Hossam Eldeen","family":"Soliman","given":"Hossam Eldeen"},{"given":"Gamal","family":"Esmat","display":"Esmat, Gamal","role":"aut"},{"given":"Thomas","family":"Longerich","display":"Longerich, Thomas","role":"aut"},{"role":"aut","display":"Illig, Thomas","given":"Thomas","family":"Illig"},{"role":"aut","display":"Köhler, Bruno Christian","given":"Bruno Christian","family":"Köhler"},{"display":"Saborowski, Anna","role":"aut","family":"Saborowski","given":"Anna"},{"family":"Bantel","given":"Heike","role":"aut","display":"Bantel, Heike"},{"display":"Vogel, Arndt","role":"aut","family":"Vogel","given":"Arndt"},{"display":"Schirmacher, Peter","role":"aut","given":"Peter","family":"Schirmacher"},{"given":"Ahmed Ihab","family":"Abdelaziz","role":"aut","display":"Abdelaziz, Ahmed Ihab"},{"display":"Breuhahn, Kai","role":"aut","family":"Breuhahn","given":"Kai"}],"title":[{"subtitle":"tumor markers and signatures","title_sort":"serum lncRNA signature determines oncogenic YAP activity in cancer patients","title":"A serum lncRNA signature determines oncogenic YAP activity in cancer patients"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a ROSEFABIANSERUMLNCRN2320 | ||