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An n-acetyltransferase-MAPK fusion protein modulates developmental reprogramming in Physcomitrium patens

We discovered a previously uncharacterized moss-specific protein, Rosetta NATD-MAPK 1 (RAK1) in Physcomitrium patens, which uniquely integrates MAP kinase (MAPK)-dependent signaling with N-acetyltransferase activity. Through phenotypical and biochemical analyses, we characterized RAK1 function in th...

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Autores principales: de Luxán-Hernández, Cloe (Autor) , Ammitsøe, Thomas J. (Autor) , Kanne, Jakob V. (Autor) , Stanimirovic, Sabrina (Autor) , Redondo-Rodríguez, Rocío (Autor) , Roux, Milena E. (Autor) , Zhang, Liechi (Autor) , Weeks, Zoe (Autor) , Schutzbier, Michael (Autor) , Dürnberger, Gerhard (Autor) , Roitinger, Elisabeth (Autor) , Spadiut, Oliver (Autor) , Ishikawa, Masaki (Autor) , Hasebe, Mitsuyasu (Autor) , Moody, Laura A. (Autor) , Dagdas, Yasin (Autor) , Rodriguez, Eleazar (Autor) , Petersen, Morten (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: July 2026
In: The new phytologist
Year: 2026, Volumen: 251, Número: 1, Pages: 321-339
ISSN:1469-8137
DOI:10.1111/nph.71214
Acceso en línea:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/nph.71214
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/nph.71214
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Notas de Autor:Cloe de Luxán-Hernández, Thomas J. Ammitsøe, Jakob V. Kanne, Sabrina Stanimirovic, Rocío Redondo-Rodríguez, Milena E. Roux, Liechi Zhang, Zoe Weeks, Michael Schutzbier, Gerhard Dürnberger, Elisabeth Roitinger, Oliver Spadiut, Masaki Ishikawa, Mitsuyasu Hasebe, Laura A. Moody, Yasin F. Dagdas, Eleazar Rodriguez and Morten Petersen
Descripción
Sumario:We discovered a previously uncharacterized moss-specific protein, Rosetta NATD-MAPK 1 (RAK1) in Physcomitrium patens, which uniquely integrates MAP kinase (MAPK)-dependent signaling with N-acetyltransferase activity. Through phenotypical and biochemical analyses, we characterized RAK1 function in the regulation of the 2D-to-3D growth transition. We identified differential acetylation events associated with metabolic reprogramming in rak1 mutants and demonstrated that RAK1 has acetyltransferase activity enhanced by MAPK domain activation. Consistently, RAK1 was found to interact with proteins involved in metabolic processes. Collectively, this study uncovers a previously unknown multidomain protein and provides mechanistic insights into the interplay of post-translational modifications during developmental reprogramming.
Notas:Gesehen am 20.07.2026
Zuerst veröffentlicht: 13 May 2026
Descripción Física:Online Resource
ISSN:1469-8137
DOI:10.1111/nph.71214

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