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Experiences and expert panel consensus on bridging therapy before anti-BCMA CAR-T cell therapy in multiple myeloma

Use of anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR-T) therapy to treat relapsed/refractory multiple myeloma is increasing. Studies suggest that effective bridging therapy (BT) prior to anti-BCMA CAR-T therapy can enhance efficacy and safety outcomes. Through qualitati...

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Hauptverfasser: Rasche, Leo (Verfasst von) , Krauth, Maria Theresa (Verfasst von) , Agis, Hermine (Verfasst von) , Renner, Christoph (Verfasst von) , Strassl, Irene (Verfasst von) , Teipel, Raphael (Verfasst von) , Vučinić, Vladan (Verfasst von) , Weisel, Katja (Verfasst von) , Willenbacher, Wolfgang (Verfasst von) , Raab, Marc-Steffen (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 May 2026
In: Bone marrow transplantation
Year: 2026, Jahrgang: 61, Heft: 7, Pages: 785-790
ISSN:1476-5365
DOI:10.1038/s41409-026-02905-1
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41409-026-02905-1
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41409-026-02905-1
Volltext
Verfasserangaben:Leo Rasche, Maria Theresa Krauth, Hermine Agis, Christoph Renner, Irene Strassl, Raphael Teipel, Vladan Vučinić, Katja Weisel, Wolfgang Willenbacher and Marc S. Raab
Beschreibung
Zusammenfassung:Use of anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR-T) therapy to treat relapsed/refractory multiple myeloma is increasing. Studies suggest that effective bridging therapy (BT) prior to anti-BCMA CAR-T therapy can enhance efficacy and safety outcomes. Through qualitative interviews and a consensus workshop, 10 European experts shared their clinical experience regarding optimal BT selection, efficacy, safety and outcomes post-CAR-T, focussing on heavily pretreated patients and emerging BT options, such as bispecific T-cell engagers. Experts agreed that BT should aim to reduce tumour burden and maintain or improve patient performance status, while avoiding treatment-related toxicity that could delay or prevent CAR-T infusion. The balance between treatment duration and achieving an adequate response is important, and patient characteristics are key for BT selection, especially in difficult-to-treat populations. Here, we discuss the unique therapy talquetamab, a GPRC5DxCD3 bispecific antibody, which demonstrates robust efficacy and rapid response rates in clinical trials, and is being considered as a BT option before anti-BCMA CAR-T therapy based on expert experience and real-world data. This consensus, based on clinical experience, aims to provide guidance on BT for healthcare professionals (HCPs) involved in anti-BCMA CAR-T therapy and aid standardisation of care in this rapidly advancing field.
Beschreibung:Gesehen am 20.07.2026
Beschreibung:Online Resource
ISSN:1476-5365
DOI:10.1038/s41409-026-02905-1

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