Copertina

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt

The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Although most infections are self-limiting, zoonotic genotypes can persist in immunocompromised individuals. Transmitted via the fecal-oral route, HEV has been suggested to directly infect the intestinal epithelium, a tissu...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Prallet, Sarah (Autore) , Maier, Niclas (Autore) , Li, Albert (Autore) , Afting, Cassian (Autore) , Huang, Hao-En (Autore) , Hu, Jungen (Autore) , Toprak, Elif (Autore) , Keya, Deb Purna (Autore) , Colasanti, Ombretta (Autore) , León-Janampa, Nancy (Autore) , Marlet, Julien (Autore) , Beisel, Claudia (Autore) , Mogler, Carolin (Autore) , Puchas, Philip (Autore) , Behrendt, Patrick (Autore) , Boettler, Tobias (Autore) , Steinmann, Eike (Autore) , Saha, Senjuti (Autore) , Laketa, Vibor (Autore) , Lohmann, Volker (Autore) , Wittbrodt, Joachim (Autore) , Herrmann, Carl (Autore) , Dill, Michael T. (Autore) , Dao Thi, Viet Loan (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 1 Apr 2026
In: Science advances
Year: 2026, Volume: 12, Fascicolo: 14, Pages: 1-15
ISSN:2375-2548
DOI:10.1126/sciadv.aeb2333
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.aeb2333
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciadv.aeb2333
Testo
Note sull'autore:Sarah Prallet, Niclas Maier, Albert Li, Cassian Afting, Hao-En Huang, Jungen Hu, Elif Toprak, Deb Purna Keya, Ombretta Colasanti, Nancy León-Janampa, Julien Marlet, Claudia Beisel, Carolin Mogler, Philip Puchas, Patrick Behrendt, Tobias Boettler, Eike Steinmann, Senjuti Saha, Vibor Laketa, Volker Lohmann, Joachim Wittbrodt, Carl Hermann, Michael T. Dill, Viet Loan Dao Thi
Descrizione
Riassunto:The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Although most infections are self-limiting, zoonotic genotypes can persist in immunocompromised individuals. Transmitted via the fecal-oral route, HEV has been suggested to directly infect the intestinal epithelium, a tissue with high regenerative capacity. Here, we demonstrate that HEV predominantly infects proliferative transit-amplifying and intestinal stem cells within the crypts of human pluripotent stem cell-derived intestinal organoids (hIOs). Supporting this, we detected HEV RNA in the intestinal crypts of an HEV-infected patient. We further found that HEV infection spreads through cell division and is maintained in hIOs for more than 40 days, contrasting with acute hepatitis A virus, whose infections are rapidly cleared from hIOs. Given the self-renewal ability and metabolic constraints of proliferative intestinal progenitor cells, our findings suggest that intestinal crypts could serve as reservoirs for chronic HEV infection and highlight the intestinal crypt as a primary target for viral infection in the gastrointestinal tract.
Descrizione del documento:Gesehen am 20.07.2026
Descrizione fisica:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.aeb2333

Documenti analoghi