Thalamic nuclei volumes across psychiatric and neurological disorders: a multi-site magnetic resonance imaging study
The human thalamus is an integrative hub for multiple cortical and subcortical circuits involved in sensory processing and higher cognitive functions. Thalamic volume differences have been reported across multiple psychiatric and neurological disorders, but previous studies have typically relied on...
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
13 May 2026
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| In: |
Translational Psychiatry
Year: 2026, Volumen: 16, Pages: 1-13 |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-026-04076-5 |
| Acceso en línea: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41398-026-04076-5 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41398-026-04076-5 
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| Notas de Autor: | V. Mäki-Marttunen, S. Nerland, K.N. Jørgensen, E.A. Høgestøl, J. Rokicki, D. Alnæs, S. Borgwardt, B. Boye, J. Buitelaar, E. Bøen, S. Cervenka, A. Conzelmann, S. Erhardt, B. Franke, E.G. Celius, H.F. Harbo, E. Hilland, P. Hoekstra, C.A. Hartman, R. Jonassen, E.G. Jönsson, N.I. Landrø, K.-P. Lesch, L.A. Maglanoc, P. Pauli, C.M. Sellgren, G.O. Nygaard, J. Oosterlaan, A. Schmidt, E. Schwarz, G.C. Ziegler, I. Agartz, L.T. Westlye, O.A. Andreassen, T. Kaufmann and T. Elvsåshagen |
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| 245 | 1 | 0 | |a Thalamic nuclei volumes across psychiatric and neurological disorders |b a multi-site magnetic resonance imaging study |c V. Mäki-Marttunen, S. Nerland, K.N. Jørgensen, E.A. Høgestøl, J. Rokicki, D. Alnæs, S. Borgwardt, B. Boye, J. Buitelaar, E. Bøen, S. Cervenka, A. Conzelmann, S. Erhardt, B. Franke, E.G. Celius, H.F. Harbo, E. Hilland, P. Hoekstra, C.A. Hartman, R. Jonassen, E.G. Jönsson, N.I. Landrø, K.-P. Lesch, L.A. Maglanoc, P. Pauli, C.M. Sellgren, G.O. Nygaard, J. Oosterlaan, A. Schmidt, E. Schwarz, G.C. Ziegler, I. Agartz, L.T. Westlye, O.A. Andreassen, T. Kaufmann and T. Elvsåshagen |
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| 520 | |a The human thalamus is an integrative hub for multiple cortical and subcortical circuits involved in sensory processing and higher cognitive functions. Thalamic volume differences have been reported across multiple psychiatric and neurological disorders, but previous studies have typically relied on small samples, focused on one or a limited number of disorders, or investigated the thalamus as a whole without considering its functional subdivisions. In this multi-site study, we compared thalamic nuclei volumes across mild cognitive impairment (MCI), dementia (DEM), major depressive disorder, schizophrenia spectrum disorder (SCZ), clinical high risk for schizophrenia, bipolar spectrum disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, Parkinson’s disease, multiple sclerosis (MS), and healthy controls (N > 8000). Using structural MRI, we segmented 25 bilateral thalamic nuclei, corresponding to six anatomical groups. Linear models revealed that anterior, medial and lateral regions of the thalamus were significantly smaller in several conditions, with largest effects observed for MCI, DEM, SCZ and MS. In contrast, the ventral and intralaminar groups were relatively normal. This pattern of effects largely corresponds to the canonical functional subdivision of the thalamus into higher-order and sensory regions. At the level of individual nuclei, the clinical conditions were associated with distinct patterns of alterations, while left and right lateral geniculate nuclei were implicated in six of the disorders, suggesting a possible relation with circadian and sleep disturbances. Together, the results highlight a role for the higher-order thalamus in common brain disorders and a differential involvement at the nuclei level, refining our understanding of thalamic pathology across common brain disorders. | ||
| 650 | 4 | |a Diagnostic markers | |
| 650 | 4 | |a Physiology | |
| 700 | 1 | |a Nerland, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jørgensen, K. N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Høgestøl, E. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rokicki, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alnæs, D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Borgwardt, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boye, B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buitelaar, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bøen, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cervenka, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Conzelmann, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Erhardt, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Franke, B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Celius, E. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harbo, H. F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hilland, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoekstra, P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hartman, C. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jonassen, R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jönsson, E. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Landrø, N. I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lesch, K.-P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maglanoc, L. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pauli, P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sellgren, C. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nygaard, G. O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oosterlaan, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmidt, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwarz, Emanuel |e VerfasserIn |0 (DE-588)1055051260 |0 (DE-627)792581040 |0 (DE-576)411121596 |4 aut | |
| 700 | 1 | |a Ziegler, G. C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Agartz, I. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Andreassen, O. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaufmann, T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Elvsåshagen, T. |e VerfasserIn |4 aut | |
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