Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors: expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1
This study aims to evaluate two advanced reasoning LLMs in generating treatment recommendations for real-world gastrointestinal stromal tumor (GIST) cases and assess their concordance with multidisciplinary team (MDT) decisions at a certified tertiary sarcoma center.
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
18 May 2026
|
| In: |
Journal of cancer research and clinical oncology
Year: 2026, Volumen: 152, Número: 7, Pages: 1-10 |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-026-06489-7 |
| Acceso en línea: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00432-026-06489-7 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00432-026-06489-7 
|
| Notas de Autor: | Melissa Harbrücker, Franka Menge, Arshia Taebi, Dominik Nörenberg, Tobias Speer, Christoph Reißfelder, Peter Hohenberger, Jens Jakob, Chengpeng Li, Cui Yang |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1980606595 | ||
| 003 | DE-627 | ||
| 005 | 20260731145430.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260731s2026 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00432-026-06489-7 |2 doi | |
| 035 | |a (DE-627)1980606595 | ||
| 035 | |a (DE-599)KXP1980606595 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Harbrücker, Melissa |d 1996- |e VerfasserIn |0 (DE-588)125046207X |0 (DE-627)1787340600 |4 aut | |
| 245 | 1 | 0 | |a Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors |b expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1 |c Melissa Harbrücker, Franka Menge, Arshia Taebi, Dominik Nörenberg, Tobias Speer, Christoph Reißfelder, Peter Hohenberger, Jens Jakob, Chengpeng Li, Cui Yang |
| 264 | 1 | |c 18 May 2026 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 18. Mai 2026, Artikelversion: 13. Juli 2026 | ||
| 500 | |a Gesehen am 31.07.2026 | ||
| 520 | |a This study aims to evaluate two advanced reasoning LLMs in generating treatment recommendations for real-world gastrointestinal stromal tumor (GIST) cases and assess their concordance with multidisciplinary team (MDT) decisions at a certified tertiary sarcoma center. | ||
| 650 | 4 | |a Large language model | |
| 650 | 4 | |a Artificial intelligence | |
| 650 | 4 | |a Decision-making | |
| 650 | 4 | |a Gastrointestinal stromal tumor | |
| 650 | 4 | |a Human-in-the-loop | |
| 650 | 4 | |a Multidisciplinary | |
| 700 | 1 | |a Menge, Franka |d 1970- |e VerfasserIn |0 (DE-588)118076744 |0 (DE-627)694650471 |0 (DE-576)291702260 |4 aut | |
| 700 | 1 | |a Taebi, Arshia |d 2000- |e VerfasserIn |0 (DE-588)1415095612 |0 (DE-627)1980607664 |4 aut | |
| 700 | 1 | |a Nörenberg, Dominik |e VerfasserIn |0 (DE-588)1064719996 |0 (DE-627)814432123 |0 (DE-576)424084228 |4 aut | |
| 700 | 1 | |a Speer, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reißfelder, Christoph |d 1975- |e VerfasserIn |0 (DE-588)1025566211 |0 (DE-627)722940297 |0 (DE-576)370516044 |4 aut | |
| 700 | 1 | |a Hohenberger, Peter |d 1953- |e VerfasserIn |0 (DE-588)1025311469 |0 (DE-627)72202875X |0 (DE-576)370195574 |4 aut | |
| 700 | 1 | |a Jakob, Jens |d 1974- |e VerfasserIn |0 (DE-588)129491128 |0 (DE-627)470196335 |0 (DE-576)297687794 |4 aut | |
| 700 | 1 | |a Li, Chengpeng |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yang, Cui |d 1984- |e VerfasserIn |0 (DE-588)1136151982 |0 (DE-627)891949968 |0 (DE-576)490363180 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cancer research and clinical oncology |d Berlin : Springer, 1979 |g 152(2026), 7, Artikel-ID 136, Seite 1-10 |h Online-Ressource |w (DE-627)253769515 |w (DE-600)1459285-X |w (DE-576)072578319 |x 1432-1335 |7 nnas |a Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1 |
| 773 | 1 | 8 | |g volume:152 |g year:2026 |g number:7 |g elocationid:136 |g pages:1-10 |g extent:10 |a Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00432-026-06489-7 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00432-026-06489-7 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260731 | ||
| 993 | |a Article | ||
| 994 | |a 2026 | ||
| 998 | |g 1136151982 |a Yang, Cui |m 1136151982:Yang, Cui |d 60000 |d 61800 |e 60000PY1136151982 |e 61800PY1136151982 |k 0/60000/ |k 1/60000/61800/ |p 10 |y j | ||
| 998 | |g 129491128 |a Jakob, Jens |m 129491128:Jakob, Jens |d 60000 |d 61800 |e 60000PJ129491128 |e 61800PJ129491128 |k 0/60000/ |k 1/60000/61800/ |p 8 | ||
| 998 | |g 1025311469 |a Hohenberger, Peter |m 1025311469:Hohenberger, Peter |d 60000 |d 61800 |e 60000PH1025311469 |e 61800PH1025311469 |k 0/60000/ |k 1/60000/61800/ |p 7 | ||
| 998 | |g 1025566211 |a Reißfelder, Christoph |m 1025566211:Reißfelder, Christoph |d 60000 |d 61800 |e 60000PR1025566211 |e 61800PR1025566211 |k 0/60000/ |k 1/60000/61800/ |p 6 | ||
| 998 | |g 1064719996 |a Nörenberg, Dominik |m 1064719996:Nörenberg, Dominik |d 60000 |d 62900 |e 60000PN1064719996 |e 62900PN1064719996 |k 0/60000/ |k 1/60000/62900/ |p 4 | ||
| 998 | |g 1415095612 |a Taebi, Arshia |m 1415095612:Taebi, Arshia |d 60000 |e 60000PT1415095612 |k 0/60000/ |p 3 | ||
| 998 | |g 118076744 |a Menge, Franka |m 118076744:Menge, Franka |d 60000 |d 61800 |e 60000PM118076744 |e 61800PM118076744 |k 0/60000/ |k 1/60000/61800/ |p 2 | ||
| 998 | |g 125046207X |a Harbrücker, Melissa |m 125046207X:Harbrücker, Melissa |d 60000 |d 61800 |e 60000PH125046207X |e 61800PH125046207X |k 0/60000/ |k 1/60000/61800/ |p 1 |x j | ||
| 999 | |a KXP-PPN1980606595 |e 5004243166 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online veröffentlicht: 18. Mai 2026, Artikelversion: 13. Juli 2026","Gesehen am 31.07.2026"],"origin":[{"dateIssuedKey":"2026","dateIssuedDisp":"18 May 2026"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1980606595","language":["eng"],"title":[{"subtitle":"expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1","title":"Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors","title_sort":"Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors"}],"relHost":[{"recId":"253769515","title":[{"title_sort":"Journal of cancer research and clinical oncology","title":"Journal of cancer research and clinical oncology","subtitle":"official organ of the Deutsche Krebsgesellschaft"}],"language":["eng","ger"],"disp":"Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1Journal of cancer research and clinical oncology","note":["Gesehen am 19.03.25","Teils ungezählte Beil.: Supplement"],"origin":[{"publisher":"Springer","publisherPlace":"Berlin ; Heidelberg","dateIssuedKey":"1979","dateIssuedDisp":"1979-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["Volume 93, issue 1 (January 1979)-"],"id":{"zdb":["1459285-X"],"eki":["253769515"],"issn":["1432-1335"]},"part":{"pages":"1-10","year":"2026","extent":"10","text":"152(2026), 7, Artikel-ID 136, Seite 1-10","volume":"152","issue":"7"},"titleAlt":[{"title":"Cancer research and clinical oncology"}]}],"name":{"displayForm":["Melissa Harbrücker, Franka Menge, Arshia Taebi, Dominik Nörenberg, Tobias Speer, Christoph Reißfelder, Peter Hohenberger, Jens Jakob, Chengpeng Li, Cui Yang"]},"person":[{"given":"Melissa","role":"aut","family":"Harbrücker","display":"Harbrücker, Melissa"},{"family":"Menge","display":"Menge, Franka","role":"aut","given":"Franka"},{"given":"Arshia","role":"aut","family":"Taebi","display":"Taebi, Arshia"},{"display":"Nörenberg, Dominik","family":"Nörenberg","role":"aut","given":"Dominik"},{"given":"Tobias","display":"Speer, Tobias","family":"Speer","role":"aut"},{"given":"Christoph","display":"Reißfelder, Christoph","family":"Reißfelder","role":"aut"},{"role":"aut","display":"Hohenberger, Peter","family":"Hohenberger","given":"Peter"},{"given":"Jens","role":"aut","family":"Jakob","display":"Jakob, Jens"},{"display":"Li, Chengpeng","family":"Li","role":"aut","given":"Chengpeng"},{"given":"Cui","display":"Yang, Cui","family":"Yang","role":"aut"}],"physDesc":[{"noteIll":"Illustrationen","extent":"10 S."}],"id":{"eki":["1980606595"],"doi":["10.1007/s00432-026-06489-7"]}} | ||
| SRT | |a HARBRUECKEEVALUATING1820 | ||