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Maternal-infant immune signatures in infants at risk for SARS-CoV-2-associated neurodevelopmental disorders

Maternal immune activation during pregnancy has been associated with abnormal infant neurodevelopment. During the COVID-19 pandemic, we enrolled pregnant individuals with laboratory-confirmed SARS-CoV-2 infection into a cohort study conducted in Los Angeles, United States, and Rio de Janeiro, Brazil...

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Autores principales: Fajardo-Martinez, Viviana (Autor) , Ferreira, Fatima (Autor) , Salem, Gielenny M. (Autor) , Saleh, Tawny (Autor) , Mohole, Jyodi (Autor) , Fuller, Trevon (Autor) , Cambou, Mary Catherine (Autor) , Kerin, Tara (Autor) , Rao, Rashmi (Autor) , Zhang, Dajie (Autor) , Marschik, Peter B. (Autor) , Wilson, Rujuta B. (Autor) , Moreira, Maria Elisabeth L. (Autor) , Jung, Jae U. (Autor) , Chen, Weiqiang (Autor) , Foo, Suan-Sin (Autor) , Brasil, Patricia (Autor) , Nielsen-Saines, Karin (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 21 April 2026
In: Communications biology
Year: 2026, Volumen: 9, Pages: 1-9
ISSN:2399-3642
DOI:10.1038/s42003-026-10019-z
Acceso en línea:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s42003-026-10019-z
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s42003-026-10019-z
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Notas de Autor:Viviana Fajardo-Martinez, Fatima Ferreira, Gielenny M. Salem, Tawny Saleh, Jyodi Mohole, Trevon Fuller, Mary Catherine Cambou, Tara Kerin, Rashmi Rao, Dajie Zhang, Peter Marschik, Rujuta B. Wilson, Maria Elisabeth L. Moreira, Jae U. Jung, Weiqiang Chen, Suan-Sin Foo, Patricia Brasil & Karin Nielsen-Saines
Descripción
Sumario:Maternal immune activation during pregnancy has been associated with abnormal infant neurodevelopment. During the COVID-19 pandemic, we enrolled pregnant individuals with laboratory-confirmed SARS-CoV-2 infection into a cohort study conducted in Los Angeles, United States, and Rio de Janeiro, Brazil, and monitored their infants for neurodevelopmental outcomes. We reported a ten-fold higher rate of developmental delay in 172 SARS-CoV-2-exposed children (11.6%) compared to 128 pre-pandemic controls (1.6%) and a nearly 2-fold higher frequency of positive screens for autism spectrum disorder (ASD) in 218 SARS-CoV-2-exposed (10.1%) children as compared to 527 unexposed control children (5.7%) evaluated through standardized developmental tools. To identify potential biomarkers of SARS-CoV-2-associated risk of abnormal infant neurodevelopment, we evaluated the serum immunoprofiles of a subset of mother-infant dyads from this cohort. Serum proteomics profiling of 34 newborns (27 SARS-CoV-2-exposed and 7 controls) revealed 62 biomarkers dysregulated in SARS-CoV-2-exposed children at risk for neurodevelopmental disorders, including activation of nicotinamide biosynthesis, microglial cells, and neutrophil extravasation. Maternal serum profiling of 51 women (33 SARS-CoV-2-positive and 18 controls) identified 34 biomarkers associated with upregulated apoptosis signaling in COVID-19 affected pregnancies. Our findings suggest prenatal SARS-CoV-2 infection is potentially associated with dysregulation of maternal-infant peripheral immunity profiles reportedly associated with neurodevelopmental disorders.
Notas:Veröffentlicht: 21. April 2026
Gesehen am 14.08.2026
Descripción Física:Online Resource
ISSN:2399-3642
DOI:10.1038/s42003-026-10019-z

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