Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients: a multicentre real-world study : transplantation & cellular therapy
Patients with relapsed or refractory acute myeloid leukaemia (r/r AML) harbouring FMS-like tyrosine kinase 3 (FLT3) mutations generally have poor prognosis and limited treatment options. The second-generation FLT3 inhibitor gilteritinib provides better disease control compared to standard relapse th...
Salvato in:
| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
2026
|
| In: |
British journal of haematology
Year: 2026, Pages: 1-14 |
| ISSN: | 1365-2141 |
| DOI: | 10.1111/bjh.70735 |
| Accesso online: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/bjh.70735 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.70735 
|
| Note sull'autore: | Desiree Kunadt, Sven Zukunft, Christoph Röllig, Stephan Metzelder, Andreas Burchert, Eva Wagner-Drouet, Oliver Kriege, Christoph Schliemann, Matthias Stelljes, Julian Ronnacker, Wolfgang Bethge, Jan Frederic Weller, Björn Steffen, Gesine Bug, Khouloud Kouidri, Claudia Baldus, Lars Fransecky, Elisa Sala, Uwe Platzbecker, Klaus Metzeler, Sabine Kayser, Inken Hilgendorf, Andreas Hochhaus, Tim H. Brümmendorf, Edgar Jost, Anna Dorottya Doleschall, Thomas Schroeder, Jennifer Kaivers, Lambros Kordelas, Udo Holtick, Julia M. Unglaub, Tim Sauer, Paul Sebastian Jäger, Guido Kobbe, Elena Stauffer, Johanna Tischer, Tobias Herold, Normann Steiner, David Nachbaur, Nicolaus Kröger, Jochen J. Frietsch, Sabrina Kraus, Hermann Einsele, Mathias Hänel, Judith Schaffrath, William Krüger, Anne Brandenburg, Tobias A.W. Holderried, Laura Reinhardt, Markus Maulhardt, Christian Thiede, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Friedrich Stölzel, for the German Cooperative Transplant Study Group and Study Alliance Leukemia (SAL) |
MARC
| LEADER | 00000naa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1982934166 | ||
| 003 | DE-627 | ||
| 005 | 20260901142441.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260901s2026 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/bjh.70735 |2 doi | |
| 035 | |a (DE-627)1982934166 | ||
| 035 | |a (DE-599)KXP1982934166 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kunadt, Désirée |d 1990- |e VerfasserIn |0 (DE-588)1160561087 |0 (DE-627)1023831775 |0 (DE-576)50601830X |4 aut | |
| 245 | 1 | 0 | |a Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients |b a multicentre real-world study : transplantation & cellular therapy |c Desiree Kunadt, Sven Zukunft, Christoph Röllig, Stephan Metzelder, Andreas Burchert, Eva Wagner-Drouet, Oliver Kriege, Christoph Schliemann, Matthias Stelljes, Julian Ronnacker, Wolfgang Bethge, Jan Frederic Weller, Björn Steffen, Gesine Bug, Khouloud Kouidri, Claudia Baldus, Lars Fransecky, Elisa Sala, Uwe Platzbecker, Klaus Metzeler, Sabine Kayser, Inken Hilgendorf, Andreas Hochhaus, Tim H. Brümmendorf, Edgar Jost, Anna Dorottya Doleschall, Thomas Schroeder, Jennifer Kaivers, Lambros Kordelas, Udo Holtick, Julia M. Unglaub, Tim Sauer, Paul Sebastian Jäger, Guido Kobbe, Elena Stauffer, Johanna Tischer, Tobias Herold, Normann Steiner, David Nachbaur, Nicolaus Kröger, Jochen J. Frietsch, Sabrina Kraus, Hermann Einsele, Mathias Hänel, Judith Schaffrath, William Krüger, Anne Brandenburg, Tobias A.W. Holderried, Laura Reinhardt, Markus Maulhardt, Christian Thiede, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Friedrich Stölzel, for the German Cooperative Transplant Study Group and Study Alliance Leukemia (SAL) |
| 264 | 1 | |c 2026 | |
| 300 | |b Diagramme | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Erstmals veröffentlicht: 18. August 2026 | ||
| 500 | |a Gesehen am 01.09.2026 | ||
| 520 | |a Patients with relapsed or refractory acute myeloid leukaemia (r/r AML) harbouring FMS-like tyrosine kinase 3 (FLT3) mutations generally have poor prognosis and limited treatment options. The second-generation FLT3 inhibitor gilteritinib provides better disease control compared to standard relapse therapies and was approved based on two randomized trials. We analysed its efficacy and safety in a real-world cohort of r/r AML patients undergoing gilteritinib treatment including allogeneic haematopoietic stem cell transplantation (alloHSCT). Data were collected from all consecutive r/r AML patients with FLT3-internal tandem duplication and/or FLT3-tyrosine kinase domain mutations receiving gilteritinib at 25 centres. Response and survival were analysed using descriptive and correlative statistics. A total of 156 patients were analysed, 55.1% with relapse after previous alloHSCT, and 46.2% with prior FLT3 inhibitor exposure. The overall complete remission/incomplete remission (CR/Cri) rate was 45.3%, with a median overall survival (OS) of 10.0 months. Patients receiving gilteritinib only had a 1-year OS of 34%, while those with consolidating alloHSCT had a 1-year OS of 76%-92%, depending on gilteritinib maintenance post-transplant. Resuming gilteritinib post-transplant led to an 85.7% CR/CRi rate. Our real-world data confirm that gilteritinib is an effective single-agent therapy for r/r AML with FLT3 mutations, with best outcomes when used as a bridge to transplant and post-transplant maintenance. | ||
| 540 | |q DE-3 |a Namensnennung 4.0 International |f CC BY 4.0 |2 cc |u https://creativecommons.org/licenses/by/4.0/ | ||
| 650 | 4 | |a allogeneic haematopoietic stem cell transplantation | |
| 650 | 4 | |a AML | |
| 650 | 4 | |a FLT3 | |
| 650 | 4 | |a gilteritinib | |
| 650 | 4 | |a maintenance | |
| 650 | 4 | |a relapse | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Zukunft, Sven |e VerfasserIn |4 aut | |
| 700 | 1 | |a Röllig, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Metzelder, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Burchert, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wagner-Drouet, Eva |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kriege, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schliemann, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stelljes, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ronnacker, Julian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bethge, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weller, Jan Frederic |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steffen, Björn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bug, Gesine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kouidri, Khouloud |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baldus, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fransecky, Lars |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sala, Elisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Platzbecker, Uwe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Metzeler, Klaus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kayser, Sabine |d 1979- |e VerfasserIn |0 (DE-588)138694923 |0 (DE-627)605256233 |0 (DE-576)30778813X |4 aut | |
| 700 | 1 | |a Hilgendorf, Inken |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hochhaus, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brümmendorf, Tim H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jost, Edgar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Doleschall, Anna Dorottya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schroeder, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaivers, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kordelas, Lambros |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holtick, Udo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Unglaub, Julia Marie |e VerfasserIn |0 (DE-588)1247235157 |0 (DE-627)1780861508 |4 aut | |
| 700 | 1 | |a Sauer, Tim |d 1981- |e VerfasserIn |0 (DE-588)138282013 |0 (DE-627)601099516 |0 (DE-576)307058166 |4 aut | |
| 700 | 1 | |a Jäger, Paul Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kobbe, Guido |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stauffer, Elena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tischer, Johanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herold, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steiner, Normann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nachbaur, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kröger, Nicolaus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Frietsch, Jochen J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kraus, Sabrina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Einsele, Hermann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hänel, Mathias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schaffrath, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krüger, William |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brandenburg, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holderried, Tobias A. W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reinhardt, Laura |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maulhardt, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thiede, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bornhäuser, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schetelig, Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Middeke, Jan M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stölzel, Friedrich |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t British journal of haematology |d Oxford [u.a.] : Wiley-Blackwell, 1955 |g (2026), Seite 1-14 |h Online-Ressource |w (DE-627)269758941 |w (DE-600)1475751-5 |w (DE-576)09113997X |x 1365-2141 |7 nnas |a Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients a multicentre real-world study : transplantation & cellular therapy |
| 773 | 1 | 8 | |g year:2026 |g pages:1-14 |g extent:14 |a Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients a multicentre real-world study : transplantation & cellular therapy |
| 856 | 4 | 0 | |u https://doi.org/10.1111/bjh.70735 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.70735 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260901 | ||
| 993 | |a Article | ||
| 994 | |a 2026 | ||
| 998 | |g 138282013 |a Sauer, Tim |m 138282013:Sauer, Tim |d 910000 |d 910100 |e 910000PS138282013 |e 910100PS138282013 |k 0/910000/ |k 1/910000/910100/ |p 32 | ||
| 998 | |g 1247235157 |a Unglaub, Julia Marie |m 1247235157:Unglaub, Julia Marie |d 910000 |d 910100 |e 910000PU1247235157 |e 910100PU1247235157 |k 0/910000/ |k 1/910000/910100/ |p 31 | ||
| 998 | |g 138694923 |a Kayser, Sabine |m 138694923:Kayser, Sabine |d 60000 |d 63500 |e 60000PK138694923 |e 63500PK138694923 |k 0/60000/ |k 1/60000/63500/ |p 21 | ||
| 999 | |a KXP-PPN1982934166 |e 5027862849 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Erstmals veröffentlicht: 18. August 2026","Gesehen am 01.09.2026"],"person":[{"display":"Kunadt, Désirée","family":"Kunadt","role":"aut","given":"Désirée"},{"given":"Sven","role":"aut","family":"Zukunft","display":"Zukunft, Sven"},{"family":"Röllig","display":"Röllig, Christoph","given":"Christoph","role":"aut"},{"role":"aut","given":"Stephan","display":"Metzelder, Stephan","family":"Metzelder"},{"given":"Andreas","role":"aut","family":"Burchert","display":"Burchert, Andreas"},{"display":"Wagner-Drouet, Eva","family":"Wagner-Drouet","role":"aut","given":"Eva"},{"role":"aut","given":"Oliver","display":"Kriege, Oliver","family":"Kriege"},{"family":"Schliemann","display":"Schliemann, Christoph","given":"Christoph","role":"aut"},{"family":"Stelljes","display":"Stelljes, Matthias","given":"Matthias","role":"aut"},{"family":"Ronnacker","display":"Ronnacker, Julian","given":"Julian","role":"aut"},{"role":"aut","given":"Wolfgang","display":"Bethge, Wolfgang","family":"Bethge"},{"display":"Weller, Jan Frederic","family":"Weller","role":"aut","given":"Jan Frederic"},{"given":"Björn","role":"aut","family":"Steffen","display":"Steffen, Björn"},{"role":"aut","given":"Gesine","display":"Bug, Gesine","family":"Bug"},{"family":"Kouidri","display":"Kouidri, Khouloud","given":"Khouloud","role":"aut"},{"role":"aut","given":"Claudia","display":"Baldus, Claudia","family":"Baldus"},{"role":"aut","given":"Lars","display":"Fransecky, Lars","family":"Fransecky"},{"given":"Elisa","role":"aut","family":"Sala","display":"Sala, Elisa"},{"role":"aut","given":"Uwe","display":"Platzbecker, Uwe","family":"Platzbecker"},{"role":"aut","given":"Klaus","display":"Metzeler, Klaus","family":"Metzeler"},{"given":"Sabine","role":"aut","family":"Kayser","display":"Kayser, Sabine"},{"role":"aut","given":"Inken","display":"Hilgendorf, Inken","family":"Hilgendorf"},{"role":"aut","given":"Andreas","display":"Hochhaus, Andreas","family":"Hochhaus"},{"given":"Tim H.","role":"aut","family":"Brümmendorf","display":"Brümmendorf, Tim H."},{"given":"Edgar","role":"aut","family":"Jost","display":"Jost, Edgar"},{"role":"aut","given":"Anna Dorottya","display":"Doleschall, Anna Dorottya","family":"Doleschall"},{"family":"Schroeder","display":"Schroeder, Thomas","given":"Thomas","role":"aut"},{"given":"Jennifer","role":"aut","family":"Kaivers","display":"Kaivers, Jennifer"},{"family":"Kordelas","display":"Kordelas, Lambros","given":"Lambros","role":"aut"},{"display":"Holtick, Udo","family":"Holtick","role":"aut","given":"Udo"},{"given":"Julia Marie","role":"aut","family":"Unglaub","display":"Unglaub, Julia Marie"},{"family":"Sauer","display":"Sauer, Tim","given":"Tim","role":"aut"},{"role":"aut","given":"Paul Sebastian","display":"Jäger, Paul Sebastian","family":"Jäger"},{"given":"Guido","role":"aut","family":"Kobbe","display":"Kobbe, Guido"},{"role":"aut","given":"Elena","display":"Stauffer, Elena","family":"Stauffer"},{"display":"Tischer, Johanna","family":"Tischer","role":"aut","given":"Johanna"},{"display":"Herold, Tobias","family":"Herold","role":"aut","given":"Tobias"},{"display":"Steiner, Normann","family":"Steiner","role":"aut","given":"Normann"},{"given":"David","role":"aut","family":"Nachbaur","display":"Nachbaur, David"},{"family":"Kröger","display":"Kröger, Nicolaus","given":"Nicolaus","role":"aut"},{"family":"Frietsch","display":"Frietsch, Jochen J.","given":"Jochen J.","role":"aut"},{"given":"Sabrina","role":"aut","family":"Kraus","display":"Kraus, Sabrina"},{"given":"Hermann","role":"aut","family":"Einsele","display":"Einsele, Hermann"},{"given":"Mathias","role":"aut","family":"Hänel","display":"Hänel, Mathias"},{"role":"aut","given":"Judith","display":"Schaffrath, Judith","family":"Schaffrath"},{"display":"Krüger, William","family":"Krüger","role":"aut","given":"William"},{"display":"Brandenburg, Anne","family":"Brandenburg","role":"aut","given":"Anne"},{"role":"aut","given":"Tobias A. W.","display":"Holderried, Tobias A. W.","family":"Holderried"},{"family":"Reinhardt","display":"Reinhardt, Laura","given":"Laura","role":"aut"},{"given":"Markus","role":"aut","family":"Maulhardt","display":"Maulhardt, Markus"},{"role":"aut","given":"Christian","display":"Thiede, Christian","family":"Thiede"},{"role":"aut","given":"Martin","display":"Bornhäuser, Martin","family":"Bornhäuser"},{"given":"Johannes","role":"aut","family":"Schetelig","display":"Schetelig, Johannes"},{"role":"aut","given":"Jan M.","display":"Middeke, Jan M.","family":"Middeke"},{"role":"aut","given":"Friedrich","display":"Stölzel, Friedrich","family":"Stölzel"}],"title":[{"subtitle":"a multicentre real-world study : transplantation & cellular therapy","title_sort":"Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients","title":"Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients"}],"language":["eng"],"name":{"displayForm":["Desiree Kunadt, Sven Zukunft, Christoph Röllig, Stephan Metzelder, Andreas Burchert, Eva Wagner-Drouet, Oliver Kriege, Christoph Schliemann, Matthias Stelljes, Julian Ronnacker, Wolfgang Bethge, Jan Frederic Weller, Björn Steffen, Gesine Bug, Khouloud Kouidri, Claudia Baldus, Lars Fransecky, Elisa Sala, Uwe Platzbecker, Klaus Metzeler, Sabine Kayser, Inken Hilgendorf, Andreas Hochhaus, Tim H. Brümmendorf, Edgar Jost, Anna Dorottya Doleschall, Thomas Schroeder, Jennifer Kaivers, Lambros Kordelas, Udo Holtick, Julia M. Unglaub, Tim Sauer, Paul Sebastian Jäger, Guido Kobbe, Elena Stauffer, Johanna Tischer, Tobias Herold, Normann Steiner, David Nachbaur, Nicolaus Kröger, Jochen J. Frietsch, Sabrina Kraus, Hermann Einsele, Mathias Hänel, Judith Schaffrath, William Krüger, Anne Brandenburg, Tobias A.W. Holderried, Laura Reinhardt, Markus Maulhardt, Christian Thiede, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Friedrich Stölzel, for the German Cooperative Transplant Study Group and Study Alliance Leukemia (SAL)"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"recId":"269758941","disp":"Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia patients a multicentre real-world study : transplantation & cellular therapyBritish journal of haematology","note":["Gesehen am 08.05.08"],"language":["eng"],"pubHistory":["1.1955 -"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Oxford [u.a.] ; Oxford ; Oxford [u.a.]","publisher":"Wiley-Blackwell ; Blackwell Science ; Blackwell","dateIssuedDisp":"1955-","dateIssuedKey":"1955"}],"id":{"eki":["269758941"],"zdb":["1475751-5"],"doi":["10.1111/(ISSN)1365-2141"],"issn":["1365-2141"]},"titleAlt":[{"title":"the official journal of the British Society of Haematology"},{"title":"BJH ; the official journal of the British Society for Haematology"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"name":{"displayForm":["ed. R. B. Thompson [u.a.]"]},"corporate":[{"display":"British Society for Haematology","role":"isb"},{"display":"European Hematology Association","role":"isb"}],"part":{"text":"(2026), Seite 1-14","extent":"14","year":"2026","pages":"1-14"},"title":[{"title_sort":"British journal of haematology","subtitle":"BJHaem : an official journal of the British Society for Haematology","title":"British journal of haematology"}]}],"physDesc":[{"noteIll":"Diagramme","extent":"14 S."}],"id":{"eki":["1982934166"],"doi":["10.1111/bjh.70735"]},"origin":[{"dateIssuedDisp":"2026","dateIssuedKey":"2026"}],"recId":"1982934166"} | ||
| SRT | |a KUNADTDESITREATMENTS2026 | ||