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Construct validity of real-world digital mobility outcomes in patients after proximal femoral fracture: a cross-sectional observational study

Digital mobility outcomes (DMOs) offer unique insights into recovery of real-world mobility after proximal femoral fracture (PFF), but their clinical validity remains to be established. This study assessed construct validity (convergent, divergent, and known-groups) of 24 DMOs measuring walking acti...

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Autores principales: Eckert, Tobias (Autor) , Berge, Martin Aursand (Autor) , Long, Michael (Autor) , de las Heras, Martí (Autor) , Alvarez, Paula (Autor) , Blain, Hubert (Autor) , Braun, Julia (Autor) , Buekers, Joren (Autor) , Caulfield, Brian (Autor) , Engdal, Monika (Autor) , Frei, Anja (Autor) , Helbostad, Jorunn L. (Autor) , Ionescu, Anisoara (Autor) , Jansen, Carl-Philipp (Autor) , Johnsen, Lars Gunnar (Autor) , Klenk, Jochen (Autor) , Koch, Sarah (Autor) , Lanfranchi, Vita (Autor) , Rochester, Lynn (Autor) , Becker, Clemens (Autor) , Vereijken, Beatrix (Autor) , Garcia-Aymerich, Judith (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 20 March 2026
In: Scientific reports
Year: 2026, Volumen: 16, Número: 1
ISSN:2045-2322
DOI:10.1038/s41598-026-43297-y
Acceso en línea:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41598-026-43297-y
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-026-43297-y
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Notas de Autor:Tobias Eckert, Martin Aursand Berge, Michael Long, Martí de las Heras, Paula Alvarez, Hubert Blain, Julia Braun, Joren Buekers, Brian Caulfield, Monika Engdal, Anja Frei, Jorunn L. Helbostad, Anisoara Ionescu, Carl-Philipp Jansen, Lars Gunnar Johnsen, Jochen Klenk, Sarah Koch, Vita Lanfranchi, Lynn Rochester, Clemens Becker, Beatrix Vereijken & Judith Garcia-Aymerich
Descripción
Sumario:Digital mobility outcomes (DMOs) offer unique insights into recovery of real-world mobility after proximal femoral fracture (PFF), but their clinical validity remains to be established. This study assessed construct validity (convergent, divergent, and known-groups) of 24 DMOs measuring walking activity (amount, pattern) and gait (pace, rhythm, bout-to-bout variability) in patients within one year after PFF. Patients were recruited from inpatient and outpatient lists at five European sites, resulting in 505 included participants (66% female), with mean age of 77.6 ± 9.4 years and supervised gait speed of 0.7 ± 0.4 m/s. Mobility was monitored over seven days using a single wearable device on the lower back. Convergent and divergent validity analyses were stratified by two groups: acute (≤ 14 days since surgery) and non-acute (≥ 15 days since surgery). Correlations between DMOs and related (clinical- and patient-reported mobility outcomes) and unrelated constructs (hearing impairment and systolic blood pressure) were compared to a priori expected correlations. Known-groups validity was assessed across four recovery phases. The results were evaluated individually by experts and in a subsequent consensus meeting, with 17 of 24 DMOs showing evidence of construct validity in non-acute PFF patients. These findings represent an initial step in a larger process towards regulatory endorsement.
Notas:Gesehen am 09.09.2026
Descripción Física:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-026-43297-y

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