Infants with retinopathy of prematurity (ROP) in Germany and Türkiye: a comparison based on data from the EU-ROP registry

PurposeData on regional differences in demographics and treatment patterns for treatment-warranted retinopathy of prematurity (ROP) is limited. In this study, data from the two countries with the highest patient numbers in the EU-ROP registry, Germany and Türkiye, are analyzed.MethodsThe non-interv...

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Main Authors:	Pfeil, Johanna M. (Author) , Schnorr, Sophie C. (Author) , Meinheit, Emely (Author) , Özdek, Şengül (Author) , Uzun, Aslihan (Author) , Kara, Caner (Author) , Barth, Teresa (Author) , Yucel, Ozlem Eski (Author) , Gabel-Pfisterer, Ameli (Author) , Schöneberger, Verena (Author) , Kadayifcilar, Sibel (Author) , Bleul, Tim (Author) , Breuss, Helge (Author) , Atilla, Huban (Author) , Krohne, Tim U. (Author) , Hufendiek, Karsten (Author) , Eter, Nicole (Author) , Aisenbrey, Sabine (Author) , Skevas, Christos (Author) , Süsskind, Daniela (Author) , Schulze, Konrad (Author) , Işık, Püren (Author) , Jendritza, Waldemar (Author) , Gniesmer, Stefanie (Author) , Saßmannshausen, Marlene (Author) , Spital, Georg (Author) , Kakkassery, Vinodh (Author) , Aljarmakani, Tarek (Author) , Akkoyun, Imren (Author) , Bartmann, Iva-Ruth (Author) , Baumgarten, Sabine (Author) , Finger, Robert P. (Author) , Parlak, Melih (Author) , Chankiewitz, Erik (Author) , Stahl, Andreas (Author) , Arbaoui, Nour (Author) , Buchner, Sabine (Author) , Edelmann, Elke (Author) , Hallak, Mustafa (Author) , Kipfmüller, Florian (Author) , Koch, Sina (Author) , Schaeff, Jonathan (Author) , Selig, Sylvia (Author)
Format:	Article (Journal)
Language:	English
Published:	29 July 2026
In:	Frontiers in medicine Year: 2026, Volume: 13, Pages: 1-13
ISSN:	2296-858X
DOI:	10.3389/fmed.2026.1868323
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2026.1868323 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1868323/full
Author Notes:	Johanna M. Pfeil, Sophie C. Schnorr, Emely Meinheit, Şengül Özdek, Aslihan Uzun, Caner Kara, Teresa Barth, Ozlem Eski Yucel, Ameli Gabel-Pfisterer, Verena Schöneberger, Sibel Kadayifcilar, Tim Bleul, Helge Breuss, Huban Atilla, Tim U. Krohne, Karsten Hufendiek, Nicole Eter, Sabine Aisenbrey, Christos Skevas, Daniela Süsskind, Konrad Schulze, Püren Işık, Waldemar Jendritza, Stefanie Gniesmer, Marlene Saßmannshausen, Georg Spital, Vinodh Kakkassery, Tarek Aljarmakani, Imren Akkoyun, Iva-Ruth Bartmann, Sabine Baumgarten, Robert P. Finger, Melih Parlak, Erik Chankiewitz, Andreas Stahl and EU-ROP Study Group

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Summary:	PurposeData on regional differences in demographics and treatment patterns for treatment-warranted retinopathy of prematurity (ROP) is limited. In this study, data from the two countries with the highest patient numbers in the EU-ROP registry, Germany and Türkiye, are analyzed.MethodsThe non-interventional, multicenter European ROP registry (EU-ROP) was established in 2021 to compare various parameters related to ROP. In this evaluation, 267 treated children (516 eyes) from Germany and 198 treated children (378 eyes) from Türkiye were included. The two cohorts were compared with regard to demographics, ROP treatment parameters and retreatment rates.ResultsInfants in the German cohort had significantly lower gestational age (GA) as well as postmenstrual age (PMA) at initial treatment and (where applicable) at the time of retreatment. In the German cohort, the majority of eyes (56.1%) were treated due to stage 3 ROP in zone II with plus disease (II 3+). In the Turkish cohort, ROP II 3+ (22.0%), aggressive ROP (A-ROP) (17.9%), and ROP II 3- (17.3%) were the most common treatment indications. While ranibizumab was the predominant treatment modality in the German cohort (91.3%), about half of the eyes in the Turkish cohort were treated with laser coagulation (48.2%) while about 40% received intravitreal bevacizumab. Retreatment rates seemed to be comparable between Germany and Türkiye (28.1% vs. 27.3% of eyes) and were depending on the initial treatment method (30.5% after ranibizumab, 36.9% after bevacizumab, 14.2% after laser coagulation), although the retreatment indications [persistent avascular retina (PAR) vs. active ROP] appear to differ significantly between the two cohorts.ConclusionIn the investigated cohorts, ROP demographics, severity and treatment patterns differed significantly between Germany and Türkiye while the retreatment rate seems comparable. Different approaches to treatment of PAR may have contributed to the comparable retreatment rates despite the differences in initial treatment.
Item Description:	Mitglieder der EU-ROP Study Group: Jakob Briem, Johann Colvin, Stefan Egger, Herbert Reitsamer, Patrick Schernthaner, Sandra Stuppner, Eva Wiener, Lilyana Petrova Dimitrova, Iliyana Georgieva Ilieva, Gergana Svetoslavova, Ognyan Mitkov Mladenov, Alexander Hugo Oscar, Yanitsa Kondova-Atanassova, Vasil Marinov, Mirjana Bjelos Roncevic, Jelena Doresic, Edita Kondza Krstonijevic, Rebeka Ribičić, Jiří Dušek, David Honer, Michaela Štěpanyová, Barbora Vařejková, Piret Jüri, Liina Kala, Mikk Pauklin, Amandine Barjol, Georges Caputo, Fiammetta Catania, Florence Metge-Galatoire, L. Geerdts, Madlen Löbel, Lisa Starke, Erik Chankiewitz, Spyridon Monastiriotis, Georgia Potaki, Florian Gekeler, René Machulla, Marius Metz, Ameli Gabel-Pfisterer, Thomas Pohlenz, Julia M, Pulst Caliman, Sophie Korn, Sandra Kroll, Martina Möglich, Helge Breuß, Anne-Kathrin Retzlaff, Waldemar Jendritza, Bettina Jendritza, Zakaria Drebi, Florian Schindler, Henrik Faatz, Leonie Kläver, Andrea Koschinski, Denise Ruch, Georg Spital, Michael Petrak, Kristina Pfau, Marlene Saßmannshausen, Annika Ader, Katrin Engelmann, Ulrike Fleischer, Imke Goldammer, Vinodh Kakkassery, Grabiela Krestanova, Franziska Mühmel, Pavel Smetana, Martin Tiez, Anja Wienigk, Jemina Benga, Rainer Guthoff, Stephan Jansen, Sema Kaya, Ala Khamees, Jennifer Prues-Hölscher, Alexandra Schilcher, Verena Schöneberg, Alexander Bartsch, Lisa Dussing, Sabrina Frank, Karolina Motloch, Eva Biewald, Tobias Kiefer, Mael Lever, Philipp Rating, Tim Bleul, Alexandra T. Camp, Navid Farassat, Nikolai Gross, Lutz Joachimsen, Sebastian Küchlin, Wolf A. Lagrèze, Luca Malagutti, Fanni E. Molnár, Michael Reich, Anne Schwietering, Iva-Ruth Bartmann, Fithri Indraswari, Monika Andrassi-Darida, Kerstin Holve, Kafa Ilia, Lyubomyr Lytvynchuk, Tarek Aljarmakani, Sebastian Bemme, Jana Katharina Dieks, Mohammed Khattab, Peer Lauermann, Yulia Meyer, Hagen Bahlmann, Matthias Heckmann, Knud Linnemann, Konrad Schulze, Andreas Stahl, Allam Tayar, Hanna Faber, Nefeli Kounatidou, Caroline Lago, Laurenz Johannes Bernhard Pauleikhoff, Tim Schade, Christos Skevas, Martin Spitzer, Annabelle Volk, Jan Wildner, Denise Yang-Seeger, Anna Bajor, Anke Beckmann, Carolin Böhne, Bettina Bohnhorst, Dorothee Brockmann, Meltem Elcivan, Carsten Framme, Thomas Gröber, Melanie Haar, Jonas Herden, Karsten Hufendiek, Christoph Jacobi, Christina Jacobsen, Nils Mester, Corinna Peter, Amelie Pielen, Sabine Pirr, Tjark Rauscher, Alena Riesmeier, Lorena Stachowski, Nora Wojtera, Aida Shaghaghi Zadeh, Tim U. Krohne, Jeany Li, Nour Arbaoui, Sabine Buchner, Felix Dittgen, Elke Edelmann, Robert P. Finger, Mustafa Kamal Hallak, F. Kipfmüller, Sina Koch, Jonathan Schaeff, Sylvia Selig, Verena Englmaier, Nicole Eter, Silvia Falkenau, Barbara Glitz, Sarah Kleemann, Camila Matias, Jenny Potratz, Julia Sandkötter, Jens Storp, Maria Tekaat, Cedric Weich, Teresa Barth, Lauretta Gluth, Horst Helbig, Herbert Jägle Annette Keller-Wackerbauer, Florian Langhammer, Holger Michel, Sven Wellmann, Steffi Knappe, Sabine Baumgarten, Volker Buck, Emilia Michalewicz, Peter Walter, Tibor Lohmann, Viktorija Belousova, Maximilian Busch, Stefanie Gniesmer, Salvatore Grisanti, Julius Caspar Rotering, Christian Schiemenz, Philip Schubart, Axel Frank, Ulrike Hagemann, Benedikt Rössler, Daniela Süsskind, Michael Völker, Britta Dahlke, Melih Parlak, Ingrid Weithmann, Armin Wolf, Johannes Kahle, Wessam Alkabouni, Sabine Aisenbrey, Lisa Fu, Marian Liegl, Melanie Michelczak, Maria Lithoxopoulou, Asimina Mataftsi, Stella Moutzouri, Christos Tsakalidis, Nikolaos Ziakas, Theodoros Gkouvas, Tataropoulou Kassandra, Agathi Kouri, Anna Mourgela, Angeliki Nika, Margarita Papadopoulou, Sofia Androudi, Maria Goudesidou, Ioanna Grivea, Katerina Kaffe, Eleni Papageorgiou, Zoi Tsani, Teodóra Dusek, Erika Maka, Miklós Szabó, Andrea Szigeti, Lilána Szücs-Székács, Mediha Bahtiri, Fjolla Bokshi, Shukrije Brajshori, Florie Greicevci, Luan Morina, Belinda Pustina, Lisa Qurdina, Ardian Shabani, Mazur Liubovi, Maria Szwajkowska, Kristof Cieslik, Agnieszka Czeszyk, Dariusz Gruszfeld, Wojciech Hautz, Beata Kocyla-Karczmarewicz, Klaudia Rakusiewicz-Krasnodȩbska, Anna Rogowska, Monika Oziȩbło-Kupczyk, Joanna Zawistowska, Magdalena Kaszuba-Modrzejewska, Bogumiła Wójcik-Niklewska, Elżbieta Czapla, Julia Dezor-Garus, Anna Gotz-Wiȩckowska, Jolanta Kaczmarek, Jan Mazela, Marta Pawlak, Tomasz Szczapa, Dawid Szpecht, Nicoleta Grosu, Mădălina Hapca, Monica Hăşmăşanu, Melinda Matyas, Simona Nicoară, Claudia Ştefănuţ, Gabriela Zaharie, Julia Escudero Gómez, Lorena Azorín-Pérez, Honorio Barranco-González, Carlos Cauto-Picazo, Isabel Pascual-Camps, Marta Solaz-Ruiz, Ester Torres-Martínez, Franscisca Barcos Munoz, Walid Bouthour, Eline De Clerck, Gunda Kann, Mateusz Kecik, Martina Kropp, Ariane Malclès, Gabriele Thumann, Tin Vo, Josep Callizo Planas, Daniela Hauenstein, Jordan Löliger, Huban Atilla, Pınar Bingöl Kızıltunç, Feyza Çalış Karanfil, Emel Okulu, Bensu Sezer, Imren Akkoyun, Ayse Ecevit, Gülsah Gökgöz, Deniz Anuk Ince, Gursel Yilmaz, Puren İsik, Hacer Yapicioglu Yildizdas, Cagatay Karaca, Mehmet Mutlu, Osman Ahmet Polat, Huseyin Pur, Ahmet Yağmur Baş, Caner Kara, Ayşen Sumru Kavurt, Betül Ortatatlı, İbrahim Murat Hirfanoğlu, Benay Karabulut, Esin Koç, Şengül Özdek, Hüseyin Baran Özdemir, Figen Bezci Aygün, Tolga Çelik, İrem İyigün, Sibel Kadayıfçılar, Ozlem Eski Yucel, Aslihan Uzun, Nilgün Köksal, Meral Yıldız, Ilke Mungan Akin, Tetiana Havrylyshyn, Paul Runge, Sergiy Lupyr, Serdeha Olha Oleksandrivna, Katsan Sergii Volodymyrovych Gesehen am 14.09.2026
Physical Description:	Online Resource
ISSN:	2296-858X
DOI:	10.3389/fmed.2026.1868323

Infants with retinopathy of prematurity (ROP) in Germany and Türkiye: a comparison based on data from the EU-ROP registry

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