Cover Image

Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene: Research article

The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor of p53 and several mechanisms of MDM2/p53 interactions are presently known: modulating...

Full description

Saved in:
Bibliographic Details
Other Authors: Mittelstraß, Kirstin (Other) , Sauter, Wiebke (Other) , Rosenberger, Albert (Other) , Illig, Thomas (Other) , Timofeeva, Maria (Other) , Klopp, Norman (Other) , Dienemann, Hendrik (Other) , Meese, Eckart (Other) , Sybrecht, Gerhard W. (Other) , Woelke, Gabi (Other) , Cebulla, Mathias (Other) , Degen, Maria (Other) , Morr, Harald (Other) , Drings, Peter (Other) , Groeschel, Andreas (Other) , Grosse Kreymborg, Karsten Roman Gregor (Other) , Haeußinger, Karl (Other) , Hoeffken, Gerd (Other) , Schmidt, Christine (Other) , Jilge, Bettina (Other) , Schmidt, Wilhelm (Performer) , Ko, You-Dschun (Performer) , Taeuscher, Dagmar (Performer) , Chang-Claude, Jenny (Performer) , Wichmann, Heinz Erich (Performer) , Bickeboeller, Heike (Performer) , Risch, Angela (Performer)
Format: Article (Journal)
Language:English
Published: 2008
In: BMC cancer
Year: 2008, Volume: 8, Pages: 1-9
ISSN:1471-2407
DOI:doi:10.1186/1471-2407-8-113
Online Access:Verlag, Volltext: http://webdoc.sub.gwdg.de/pub/med/2008/biomed/rosenberger1.pdf
Resolving-System, Volltext: http://dx.doi.org/doi:10.1186/1471-2407-8-113
Get full text
Author Notes:Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg, Karl Haeußinger, Gerd Hoeffken, Christine Schmidt, Bettina Jilge, Wilhelm Schmidt, You-Dschun Ko, Dagmar Taeuscher, Jenny Chang-Claude, Heinz-Erich Wichmann, Heike Bickeboeller and Angela Risch

MARC

LEADER 00000caa a2200000 c 4500
001 576814873
003 DE-627
005 20230426180354.0
007 cr uuu---uuuuu
008 080903s2008 xx |||||o 00| ||eng c
035 |a (DE-627)576814873 
035 |a (DE-576)9576814871 
035 |a (DE-599)GBV576814873 
035 |a (OCoLC)1340136801 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
082 0 4 |a 610  |a 614 
084 |a 33  |2 sdnb 
084 |a 44.81  |2 bkl 
084 |a 44.48  |2 bkl 
245 0 0 |a Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene  |b Research article  |c Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg, Karl Haeußinger, Gerd Hoeffken, Christine Schmidt, Bettina Jilge, Wilhelm Schmidt, You-Dschun Ko, Dagmar Taeuscher, Jenny Chang-Claude, Heinz-Erich Wichmann, Heike Bickeboeller and Angela Risch 
264 1 |c 2008 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
520 |a The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor of p53 and several mechanisms of MDM2/p53 interactions are presently known: modulating DNA-repair, cell-cycle control, cell growth and apoptosis. We used 635 Caucasian patients diagnosed with lung cancer before 51 years of age and 1300 healthy gender and age frequency matched population Caucasian controls to investigate the association between the MDM2 SNP309 and the risk of developing early onset lung cancer. Conditional logistic models were applied to assess the genotype-phenotype association, adjusted for smoking. Compared to the GG genotype, the adjusted ORs for the TG and TT genotype were 0.9 (95% CI: 0.71.5) and 1.0 (95% CI: 0.71.5), respectively. Also no association was found for histological subtypes of lung cancer. The strength of this study is that within young cases the genetic component to develop lung cancer may be greater. Our results indicate that the MDM2 SNP309 is not significantly associated with lung carcinogenesis but point towards gender-specific differences. 
538 |a Systemvoraussetzungen: Acrobat reader. 
700 1 |a Mittelstraß, Kirstin  |d 1974-  |0 (DE-588)129902349  |0 (DE-627)483349623  |0 (DE-576)297894749  |4 oth 
700 1 |a Sauter, Wiebke  |d 1973-  |0 (DE-588)129939501  |0 (DE-627)484463241  |0 (DE-576)297912658  |4 oth 
700 1 |a Rosenberger, Albert  |0 (DE-588)1183432909  |0 (DE-627)1663204772  |4 oth 
700 1 |a Illig, Thomas  |4 oth 
700 1 |a Timofeeva, Maria  |d 1981-  |0 (DE-588)137189680  |0 (DE-627)694940739  |0 (DE-576)303735791  |4 oth 
700 1 |a Klopp, Norman  |d 1969-  |0 (DE-588)123074428  |0 (DE-627)70615066X  |0 (DE-576)293543879  |4 oth 
700 1 |a Dienemann, Hendrik  |0 (DE-588)1022899406  |0 (DE-627)717328104  |0 (DE-576)366145061  |4 oth 
700 1 |a Meese, Eckart  |d 1957-  |0 (DE-588)111906539  |0 (DE-627)537492100  |0 (DE-576)289715725  |4 oth 
700 1 |a Sybrecht, Gerhard W.  |d 1943-  |0 (DE-588)1163965421  |0 (DE-627)102834774X  |0 (DE-576)508281601  |4 oth 
700 1 |a Woelke, Gabi  |4 oth 
700 1 |a Cebulla, Mathias  |d 1944-  |0 (DE-588)127466604X  |0 (DE-627)1824425570  |4 oth 
700 1 |a Degen, Maria  |4 oth 
700 1 |a Morr, Harald  |d 1944-  |0 (DE-588)1206200219  |0 (DE-627)1691959952  |4 oth 
700 1 |a Drings, Peter  |d 1939-  |0 (DE-588)107133830  |0 (DE-627)514257008  |0 (DE-576)289571065  |4 oth 
700 1 |a Groeschel, Andreas  |4 oth 
700 1 |a Grosse Kreymborg, Karsten Roman Gregor  |0 (DE-588)140052968  |0 (DE-627)615249760  |0 (DE-576)31435171X  |4 oth 
700 1 |a Haeußinger, Karl  |4 oth 
700 1 |a Hoeffken, Gerd  |4 oth 
700 1 |a Schmidt, Christine  |4 oth 
700 1 |a Jilge, Bettina  |4 oth 
700 1 |a Schmidt, Wilhelm  |4 prf 
700 1 |a Ko, You-Dschun  |4 prf 
700 1 |a Taeuscher, Dagmar  |4 prf 
700 1 |a Chang-Claude, Jenny  |0 (DE-588)1049304993  |0 (DE-627)781626188  |0 (DE-576)168344475  |4 prf 
700 1 |a Wichmann, Heinz Erich  |d 1946-  |0 (DE-588)110130057  |0 (DE-627)526966548  |0 (DE-576)166337722  |4 prf 
700 1 |a Bickeboeller, Heike  |4 prf 
700 1 |a Risch, Angela  |0 (DE-588)1076185630  |0 (DE-627)834534401  |0 (DE-576)189151749  |4 prf 
773 0 8 |i In  |t BMC cancer  |d London : BioMed Central, 2001  |g 8(2008), Artikel-ID 113, Seite 1-9  |h Online-Ressource  |w (DE-627)326643710  |w (DE-600)2041352-X  |w (DE-576)107014645  |x 1471-2407  |7 nnas  |a Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene Research article 
773 1 8 |g volume:8  |g year:2008  |g elocationid:113  |g pages:1-9  |g extent:9  |a Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene Research article 
856 4 0 |u http://webdoc.sub.gwdg.de/pub/med/2008/biomed/rosenberger1.pdf  |x Verlag  |3 Volltext 
856 4 0 |u http://dx.doi.org/doi:10.1186/1471-2407-8-113  |x Resolving-System  |3 Volltext 
936 b k |a 44.81  |j Onkologie  |0 (DE-627)106409433 
936 b k |a 44.48  |j Medizinische Genetik  |0 (DE-627)106409026 
951 |a AR 
992 |a 20200310 
993 |a Article 
994 |a 2008 
998 |g 1049304993  |a Chang-Claude, Jenny  |m 1049304993:Chang-Claude, Jenny  |d 50000  |e 50000PC1049304993  |k 0/50000/  |p 24 
998 |g 107133830  |a Drings, Peter  |m 107133830:Drings, Peter  |d 50000  |e 50000PD107133830  |k 0/50000/  |p 14 
998 |g 1206200219  |a Morr, Harald  |m 1206200219:Morr, Harald  |d 910000  |d 950000  |d 950900  |e 910000PM1206200219  |e 950000PM1206200219  |e 950900PM1206200219  |k 0/910000/  |k 1/910000/950000/  |k 2/910000/950000/950900/  |p 13 
998 |g 1022899406  |a Dienemann, Hendrik  |m 1022899406:Dienemann, Hendrik  |d 910000  |d 950000  |d 950900  |e 910000PD1022899406  |e 950000PD1022899406  |e 950900PD1022899406  |k 0/910000/  |k 1/910000/950000/  |k 2/910000/950000/950900/  |p 7 
999 |a KXP-PPN576814873  |e 3605538525 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"note":["Gesehen am 22.05.20"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"BioMed Central ; Springer","dateIssuedKey":"2001","publisherPlace":"London ; Berlin ; Heidelberg","dateIssuedDisp":"2001-"}],"title":[{"title":"BMC cancer","title_sort":"BMC cancer"}],"part":{"pages":"1-9","text":"8(2008), Artikel-ID 113, Seite 1-9","year":"2008","volume":"8","extent":"9"},"language":["eng"],"disp":"Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene Research articleBMC cancer","id":{"issn":["1471-2407"],"eki":["326643710"],"zdb":["2041352-X"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2001 -"],"recId":"326643710"}],"id":{"eki":["576814873"]},"recId":"576814873","name":{"displayForm":["Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg, Karl Haeußinger, Gerd Hoeffken, Christine Schmidt, Bettina Jilge, Wilhelm Schmidt, You-Dschun Ko, Dagmar Taeuscher, Jenny Chang-Claude, Heinz-Erich Wichmann, Heike Bickeboeller and Angela Risch"]},"physDesc":[{"extent":"9 S."}],"language":["eng"],"origin":[{"dateIssuedDisp":"2008","dateIssuedKey":"2008"}],"title":[{"title_sort":"Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene","subtitle":"Research article","title":"Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"oth","given":"Kirstin","display":"Mittelstraß, Kirstin","family":"Mittelstraß"},{"family":"Sauter","display":"Sauter, Wiebke","given":"Wiebke","role":"oth"},{"family":"Rosenberger","display":"Rosenberger, Albert","given":"Albert","role":"oth"},{"display":"Illig, Thomas","family":"Illig","given":"Thomas","role":"oth"},{"given":"Maria","role":"oth","family":"Timofeeva","display":"Timofeeva, Maria"},{"role":"oth","given":"Norman","family":"Klopp","display":"Klopp, Norman"},{"given":"Hendrik","role":"oth","family":"Dienemann","display":"Dienemann, Hendrik"},{"given":"Eckart","role":"oth","display":"Meese, Eckart","family":"Meese"},{"display":"Sybrecht, Gerhard W.","family":"Sybrecht","given":"Gerhard W.","role":"oth"},{"role":"oth","given":"Gabi","display":"Woelke, Gabi","family":"Woelke"},{"given":"Mathias","role":"oth","family":"Cebulla","display":"Cebulla, Mathias"},{"display":"Degen, Maria","family":"Degen","given":"Maria","role":"oth"},{"display":"Morr, Harald","family":"Morr","role":"oth","given":"Harald"},{"display":"Drings, Peter","family":"Drings","role":"oth","given":"Peter"},{"role":"oth","given":"Andreas","display":"Groeschel, Andreas","family":"Groeschel"},{"role":"oth","given":"Karsten Roman Gregor","display":"Grosse Kreymborg, Karsten Roman Gregor","family":"Grosse Kreymborg"},{"family":"Haeußinger","display":"Haeußinger, Karl","role":"oth","given":"Karl"},{"family":"Hoeffken","display":"Hoeffken, Gerd","given":"Gerd","role":"oth"},{"display":"Schmidt, Christine","family":"Schmidt","role":"oth","given":"Christine"},{"role":"oth","given":"Bettina","display":"Jilge, Bettina","family":"Jilge"},{"role":"prf","given":"Wilhelm","family":"Schmidt","display":"Schmidt, Wilhelm"},{"display":"Ko, You-Dschun","family":"Ko","role":"prf","given":"You-Dschun"},{"family":"Taeuscher","display":"Taeuscher, Dagmar","role":"prf","given":"Dagmar"},{"role":"prf","given":"Jenny","display":"Chang-Claude, Jenny","family":"Chang-Claude"},{"role":"prf","given":"Heinz Erich","display":"Wichmann, Heinz Erich","family":"Wichmann"},{"role":"prf","given":"Heike","display":"Bickeboeller, Heike","family":"Bickeboeller"},{"role":"prf","given":"Angela","display":"Risch, Angela","family":"Risch"}]} 
SRT |a EARLYONSET2008 

Similar Items