Cover Image

Current research in head and neck cancer: molecular pathways, novel therapeutic targets, and prognostic factors ; new insights into basic and translational research

The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenanc...

Full description

Saved in:
Bibliographic Details
Other Authors: Bier, Henning (Editor)
Format: Book/Monograph
Language:English
Published: Basel Karger 2005
Series:Advances in oto-rhino-laryngology 62
In: Advances in oto-rhino-laryngology (62)

Volumes / Articles: Show Volumes / Articles.
DOI:10.1159/isbn.978-3-318-01119-7
Online Access:Resolving-System, Volltext: http://dx.doi.org/10.1159/isbn.978-3-318-01119-7
Verlag, lizenzpflichtig: https://karger.com/books/book/2486
Get full text
Author Notes:vol. ed.: Henning Bier

MARC

LEADER 00000cam a2200000 c 4500
001 621662070
003 DE-627
005 20250321135829.0
007 cr uuu---uuuuu
008 100320s2005 sz |||||o 00| ||eng c
020 |a 9783318011197  |9 978-3-318-01119-7 
024 7 |a 10.1159/isbn.978-3-318-01119-7  |2 doi 
035 |a (DE-627)621662070 
035 |a (DE-576)9621662079 
035 |a (DE-599)BVBBV036069091 
035 |a (OCoLC)837652597 
035 |a (DE-604)BV036069091 
035 |a (SZ-BaSKA)230434 
035 |a (DE-627-1)05043375X 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
044 |c XA-CH 
060 0 |a WE 707 
084 |a 33  |2 sdnb 
245 0 0 |a Current research in head and neck cancer  |b molecular pathways, novel therapeutic targets, and prognostic factors ; new insights into basic and translational research  |c vol. ed.: Henning Bier 
264 1 |a Basel  |b Karger  |c 2005 
300 |a VI + 208 S. 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
490 1 |a Advances in oto-rhino-laryngology  |v 62 
520 |a The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors.This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research 
533 |a Reproduktion  |e Online-Ressource  |f Karger eBooks Collection 1997-2009 
650 2 |a Head and Neck Neoplasms  |x genetics 
650 2 |a Genes, Tumor Suppressor 
650 2 |a Head and Neck Neoplasms  |x therapy 
650 4 |a Cell Biology 
650 4 |a Immunology 
650 4 |a Molecular Biology 
650 4 |a Oncology 
650 4 |a Otorhinolaryngology 
700 1 |a Bier, Henning  |d 1957-2018  |e Hrsg.  |0 (DE-588)129675091  |0 (DE-627)707293049  |0 (DE-576)297780441  |4 edt 
776 1 |z 9783805577892 
776 0 8 |i Erscheint auch als  |n Druck-Ausgabe  |z 9783805577892 
830 0 |a Advances in oto-rhino-laryngology  |v 62  |9 62  |w (DE-627)61751271X  |w (DE-576)351760520  |w (DE-600)2534915-6  |x 1662-2847  |7 am 
856 4 0 |u http://dx.doi.org/10.1159/isbn.978-3-318-01119-7  |x Resolving-System  |3 Volltext 
856 4 0 |u https://karger.com/books/book/2486  |m X:KARGER  |x Verlag  |z lizenzpflichtig 
912 |a ZDB-1-KEB  |b 1997-2013 
912 |a ZDB-25-KRG  |b 2005 
912 |a ZDB-25-KSE 
951 |a BO 
992 |a 20220401 
999 |a KXP-PPN621662070  |e 4109705282 
BIB |a Y 
SPR |a Y 
JSO |a {"relMultPart":[{"id":{"eki":["61751271X"],"zdb":["2534915-6"],"issn":["1662-2847"]},"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"1970-","dateIssuedKey":"1970","publisher":"Karger"}],"physDesc":[{"extent":"Online-Ressource"}],"dispAlt":"Advances in oto-rhino-laryngology","title":[{"title_sort":"Advances in oto-rhino-laryngology","title":"Advances in oto-rhino-laryngology","subtitle":" = Fortschritte der Hals-, Nasen-, Ohrenheilkunde = Progrès en oto-rhino-laryngologie"}],"language":["eng"],"recId":"61751271X","note":["Gesehen am 28.06.2024"],"type":{"media":"Online-Ressource","bibl":"serial"},"disp":"Advances in oto-rhino-laryngology","part":{"number":["62"],"number_sort":["62"]},"titleTranslated":[{"translated":"Fortschritte der Hals-, Nasen-, Ohrenheilkunde"},{"translated":"Progrès en oto-rhino-laryngologie"}],"pubHistory":["Vol. 17-"]}],"type":{"media":"Online-Ressource","bibl":"edited-book"},"physDesc":[{"extent":"VI + 208 S."}],"recId":"621662070","language":["eng"],"title":[{"title_sort":"Current research in head and neck cancer","subtitle":"molecular pathways, novel therapeutic targets, and prognostic factors ; new insights into basic and translational research","title":"Current research in head and neck cancer"}],"origin":[{"dateIssuedKey":"2005","publisher":"Karger","dateIssuedDisp":"2005","publisherPlace":"Basel"}],"id":{"doi":["10.1159/isbn.978-3-318-01119-7"],"eki":["621662070"],"isbn":["9783318011197"]},"name":{"displayForm":["vol. ed.: Henning Bier"]},"person":[{"given":"Henning","family":"Bier","role":"edt","display":"Bier, Henning","roleDisplay":"Hrsg."}]} 
SRT |a CURRENTRES2005 

Similar Items