Pediatric herpes simplex virus encephalitis: a retrospective multicenter experience
Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospina...
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| Other Authors: | , , , , , , , , , , , , , , , |
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 16, 2013
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| In: |
Journal of child neurology
Year: 2013, Volume: 28, Issue: 3, Pages: 321-331 |
| ISSN: | 1708-8283 |
| DOI: | 10.1177/0883073812471428 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1177/0883073812471428 Verlag, Abstract, Volltext: http://jcn.sagepub.com/content/28/3/321.abstract 
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| Author Notes: | Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler |
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| 245 | 1 | 0 | |a Pediatric herpes simplex virus encephalitis |b a retrospective multicenter experience |c Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler |
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| 520 | |a Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospinal fluid glucose, protein, and leukocytes were normal in 6 patients.Subsequently, all but 2 showed neurologic symptoms. Diffusion-weighted neuroimaging was the most sensitive early imagingmethod. Despite acyclovir treatment, 8 patients experienced early relapses, showing movement abnormalities, impaired vigilance,and seizures. Diffuse white matter changes, found in 3 of 5 relapse patients on neuroimaging, and a negative cerebrospinal fluidherpes simplex virus polymerase chain reaction suggested inflammatory processes. All relapse patients were again treated withacyclovir, and 3 responded to additional corticosteroid treatment. Whereas outcome after relapses was poor, overall outcomewas good. No child died; 14 were asymptomatic at discharge, and neuroimaging remained normal in 7 of 30 patients studied. | ||
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