Pediatric herpes simplex virus encephalitis: a retrospective multicenter experience
Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospina...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , , , , , , , , |
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 16, 2013
|
| In: |
Journal of child neurology
Year: 2013, Volume: 28, Issue: 3, Pages: 321-331 |
| ISSN: | 1708-8283 |
| DOI: | 10.1177/0883073812471428 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1177/0883073812471428 Verlag, Abstract, Volltext: http://jcn.sagepub.com/content/28/3/321.abstract 
|
| Author Notes: | Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 77395984X | ||
| 003 | DE-627 | ||
| 005 | 20240130194126.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 131210s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/0883073812471428 |2 doi | |
| 035 | |a (DE-627)77395984X | ||
| 035 | |a (DE-576)9773959848 | ||
| 035 | |a (DE-599)GBV77395984X | ||
| 035 | |a (OCoLC)1340138404 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schleede, Lena |0 (DE-588)1066494312 |0 (DE-627)817635351 |0 (DE-576)426007794 |4 aut | |
| 245 | 1 | 0 | |a Pediatric herpes simplex virus encephalitis |b a retrospective multicenter experience |c Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler |
| 264 | 1 | |c January 16, 2013 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.07.2021 | ||
| 520 | |a Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospinal fluid glucose, protein, and leukocytes were normal in 6 patients.Subsequently, all but 2 showed neurologic symptoms. Diffusion-weighted neuroimaging was the most sensitive early imagingmethod. Despite acyclovir treatment, 8 patients experienced early relapses, showing movement abnormalities, impaired vigilance,and seizures. Diffuse white matter changes, found in 3 of 5 relapse patients on neuroimaging, and a negative cerebrospinal fluidherpes simplex virus polymerase chain reaction suggested inflammatory processes. All relapse patients were again treated withacyclovir, and 3 responded to additional corticosteroid treatment. Whereas outcome after relapses was poor, overall outcomewas good. No child died; 14 were asymptomatic at discharge, and neuroimaging remained normal in 7 of 30 patients studied. | ||
| 700 | 1 | |a Büter, Wolfgang |d 1978- |0 (DE-588)133226069 |0 (DE-627)538689749 |0 (DE-576)299708047 |4 oth | |
| 700 | 1 | |a Baumgartner-Sigl, Sara |4 oth | |
| 700 | 1 | |a Opladen, Thomas |d 1974- |0 (DE-588)124489656 |0 (DE-627)642820481 |0 (DE-576)335321291 |4 oth | |
| 700 | 1 | |a Weigt-Usinger, Katharina |d 1977- |0 (DE-588)143495828 |0 (DE-627)64657759X |0 (DE-576)337383669 |4 oth | |
| 700 | 1 | |a Stephan, Susanne |4 oth | |
| 700 | 1 | |a Smitka, Martin |d 1976- |0 (DE-588)12989012X |0 (DE-627)483342556 |0 (DE-576)297889028 |4 oth | |
| 700 | 1 | |a Leiz, Steffen |d 1970- |0 (DE-588)120262614 |0 (DE-627)696511746 |0 (DE-576)29212600X |4 oth | |
| 700 | 1 | |a Kaiser, Olaf |4 oth | |
| 700 | 1 | |a Kraus, Verena |4 oth | |
| 700 | 1 | |a Baalen, Andreas van |0 (DE-588)11440111X |0 (DE-627)691216452 |0 (DE-576)337298009 |4 oth | |
| 700 | 1 | |a Skopnik, Heino |4 oth | |
| 700 | 1 | |a Hartmann, Hans |d 1960- |0 (DE-588)136129455 |0 (DE-627)575022183 |0 (DE-576)300848935 |4 oth | |
| 700 | 1 | |a Rostasy, Kevin |4 oth | |
| 700 | 1 | |a Lücke, Thomas |0 (DE-588)135831172 |0 (DE-627)571510256 |0 (DE-576)300669623 |4 oth | |
| 700 | 1 | |a Schara, Ulrike |4 oth | |
| 700 | 1 | |a Häusler, Martin |4 oth | |
| 773 | 0 | 8 | |i In |t Journal of child neurology |d Thousand Oaks, Calif. : Sage, 1986 |g 28(2013), 3, Seite 321-331 |h Online-Ressource |w (DE-627)341359807 |w (DE-600)2068710-2 |w (DE-576)273882872 |x 1708-8283 |7 nnas |a Pediatric herpes simplex virus encephalitis a retrospective multicenter experience |
| 773 | 1 | 8 | |g volume:28 |g year:2013 |g number:3 |g pages:321-331 |g extent:11 |a Pediatric herpes simplex virus encephalitis a retrospective multicenter experience |
| 856 | 4 | 0 | |u https://doi.org/10.1177/0883073812471428 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://jcn.sagepub.com/content/28/3/321.abstract |x Verlag |y Abstract |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210701 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 124489656 |a Opladen, Thomas |m 124489656:Opladen, Thomas |d 910000 |d 910500 |e 910000PO124489656 |e 910500PO124489656 |k 0/910000/ |k 1/910000/910500/ |p 4 | ||
| 999 | |a KXP-PPN77395984X |e 3942861178 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"77395984X","note":["Gesehen am 01.07.2021"],"language":["eng"],"person":[{"family":"Schleede","display":"Schleede, Lena","role":"aut","given":"Lena"},{"family":"Büter","display":"Büter, Wolfgang","role":"oth","given":"Wolfgang"},{"given":"Sara","role":"oth","display":"Baumgartner-Sigl, Sara","family":"Baumgartner-Sigl"},{"family":"Opladen","role":"oth","given":"Thomas","display":"Opladen, Thomas"},{"family":"Weigt-Usinger","display":"Weigt-Usinger, Katharina","given":"Katharina","role":"oth"},{"family":"Stephan","display":"Stephan, Susanne","given":"Susanne","role":"oth"},{"role":"oth","given":"Martin","display":"Smitka, Martin","family":"Smitka"},{"display":"Leiz, Steffen","role":"oth","given":"Steffen","family":"Leiz"},{"family":"Kaiser","display":"Kaiser, Olaf","given":"Olaf","role":"oth"},{"family":"Kraus","role":"oth","given":"Verena","display":"Kraus, Verena"},{"role":"oth","given":"Andreas van","display":"Baalen, Andreas van","family":"Baalen"},{"family":"Skopnik","given":"Heino","role":"oth","display":"Skopnik, Heino"},{"family":"Hartmann","display":"Hartmann, Hans","given":"Hans","role":"oth"},{"display":"Rostasy, Kevin","given":"Kevin","role":"oth","family":"Rostasy"},{"family":"Lücke","display":"Lücke, Thomas","given":"Thomas","role":"oth"},{"family":"Schara","display":"Schara, Ulrike","given":"Ulrike","role":"oth"},{"family":"Häusler","display":"Häusler, Martin","role":"oth","given":"Martin"}],"relHost":[{"title":[{"title_sort":"Journal of child neurology","title":"Journal of child neurology"}],"id":{"zdb":["2068710-2"],"eki":["341359807"],"issn":["1708-8283"]},"origin":[{"publisherPlace":"Thousand Oaks, Calif. ; Littleton, Mass. ; Littleton, Mass. ; Littleton, Mass. ; Hamilton, Ont.","dateIssuedKey":"1986","publisher":"Sage ; PSG Publ. Co. ; Year Book Medical Publ. ; Mosby-Year Book Inc. ; Decker Periodicals","dateIssuedDisp":"1986-"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Pediatric herpes simplex virus encephalitis a retrospective multicenter experienceJournal of child neurology","language":["eng"],"part":{"pages":"321-331","extent":"11","year":"2013","text":"28(2013), 3, Seite 321-331","issue":"3","volume":"28"},"recId":"341359807","pubHistory":["1.1986 -"],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"name":{"displayForm":["Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"January 16, 2013"}],"id":{"doi":["10.1177/0883073812471428"],"eki":["77395984X"]},"physDesc":[{"extent":"11 S."}],"title":[{"subtitle":"a retrospective multicenter experience","title_sort":"Pediatric herpes simplex virus encephalitis","title":"Pediatric herpes simplex virus encephalitis"}]} | ||
| SRT | |a SCHLEEDELEPEDIATRICH1620 | ||