Viral Therapy of Human Cancers
Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses,...
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| Dokumenttyp: | Buch/Monographie |
| Sprache: | Englisch |
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Hoboken
Taylor and Francis
2004
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| Volumes / Articles: | Show Volumes / Articles. |
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| Online-Zugang: | Aggregator, Volltext: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=1405275
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Inhaltsangabe:
- Front cover; Preface; Contents; Contributors; Progressive Development of Viral Therapy of Human Cancers; EARLY HISTORY; VIRUSES INTERACT; FROM MICE TO MAN; POSTONCOLYTIC ANTITUMOR IMMUNITY; VIRAL ONCOLYSATES; IMMUNE REACTIONS; MORE RECENT HISTORY; VIRAL ONCOLYSIS TODAY Influenza Virus; Measles Virus; Newcastle Disease Virus; Vesicular Stomatitis Virus; Reovirus; Vaccinia Virus; Herpes Viruses; Adenoviruses; Parvoviruses; Polio-Rhinovirus Recombinants; SAFETY MEASURES AND REGULATIONS; THE FUTURE; AFTERTHOUGHTS; REFERENCES; New Biological Therapeutics; INTRODUCTION
- FARNESYL TRANSFERASE INHIBITORS c-ras*Viral Attack; Host Counterattack; Adenoviral Oncolysis; Farnsyl Transferase Inhibitors; TYROSINE KINASE INHIBITORS Imatinib Mesylate; ZD1839 Gefitinib; OSI-774 Erlotinib; PART I: RECENT DEVELOPMENTS IN VIRAL ONCOLYSIS; REFERENCES FOR INTRODUCTION AND PART I; PART II: FLAVOPIRIDOLS, PROTEIN KINASE C, METALLOPROTEINASES, AND CYCLOOXYGENASE INHIBITORS FLAVOPIRIDOLS Cyclins; Flavopiridol-Induced Apoptosis; Inhibitors; PROTEIN KINASE C INHIBITORS A Bad Kinase; Inhibitors; METALLOPROTEINASE INHIBITORS Pathophysiology; Inhibitors
- CYCLOOXYGENASE INHIBITORS EicosanoidsNonsteroidal Anti-inflammatory Agents; RECENT DEVELOPMENTS IN MOLECULAR ONCOLOGY: PARTS I AND II; REFERENCES: PART II; PART III: ANTISENSE OLIGONUCLEOTIDES AND ANTI-ANGIOGENESIS ANTISENSE OLIGONUCLEOTIDES Viral Blockade; From Anti- to Pro-Apoptosis; c-myc; ANTI-NEOANGIOGENESIS Vasculogenesis; Angiogenesis; Inhibitors of Neoangiogenesis; Monoclonal Antibodies; Antisense Technology; Vaccines; REFERENCES, PART III; PART IV. THE PREDICTIVE VALUE OF TISSUE CULTURE AND XENOGRAFT ASSAYS CULTURE SHOCK Tissue Cultures; Trypsin
- THE TELOMERES ARE GETTING SHORTER TelomeraseRapamycins, As-ODN, Lymphocytes; ONE DAY IN THE LIFE OF ''IVAN XENOGRAFTOVICH''* Paracrine Circuits; Natural Killer Cells; Insulinlike Growth Factor-R; Activated Stroma; Intercellular Adhesions; Natural Hybridomas; THE MICROVASCULAR TUMOR BED Microvasculature; Suppressors; CHEMOKINE AND CYTOKINE GROWTH FACTORS Expropriated Cytokines; Matrix Metalloproteinases and Chemokines; Mesothelioma; Catenins, Caveolins, Connexins; Autocrine Circuits; Virus-Induced Cytokines and Chemokines
- HORMONE-RELATED EVENTS IN BREAST AND PROSTATE CANCERS Complex InteractionsAstonishing Observations; MISCELLANEOUS AGENTS TESTED IN XENOGRAFTS Xenografts of Human Tumors Are Very Sensitive to Noxious and Natural Substances; Endless List of Anti-Tumor Agents and Interventions; REFERENCES, PART IV; PART V: CLINICAL EXAMPLES: MULTIPLE MYELOMA AND GLIOBLASTOMA MULTIFORME MULTIPLE MYELOMA Pathogenesis; Biotherapy; GLIOBLASTOMA MULTIFORME Pathogenesis; Biotherapy; REFERENCES, PART V; DISCUSSION; SELECTED REFERENCES; SUMMARY
- Measles Virus: Improving Natural Oncolytic Properties by Genetic Engineering
- Front cover; Preface; Contents; Contributors; Progressive Development of Viral Therapy of Human Cancers; EARLY HISTORY; VIRUSES INTERACT; FROM MICE TO MAN; POSTONCOLYTIC ANTITUMOR IMMUNITY; VIRAL ONCOLYSATES; IMMUNE REACTIONS; MORE RECENT HISTORY; VIRAL ONCOLYSIS TODAY Influenza Virus; Measles Virus; Newcastle Disease Virus; Vesicular Stomatitis Virus; Reovirus; Vaccinia Virus; Herpes Viruses; Adenoviruses; Parvoviruses; Polio-Rhinovirus Recombinants; SAFETY MEASURES AND REGULATIONS; THE FUTURE; AFTERTHOUGHTS; REFERENCES; New Biological Therapeutics; INTRODUCTION
- FARNESYL TRANSFERASE INHIBITORS c-ras*Viral Attack; Host Counterattack; Adenoviral Oncolysis; Farnsyl Transferase Inhibitors; TYROSINE KINASE INHIBITORS Imatinib Mesylate; ZD1839 Gefitinib; OSI-774 Erlotinib; PART I: RECENT DEVELOPMENTS IN VIRAL ONCOLYSIS; REFERENCES FOR INTRODUCTION AND PART I; PART II: FLAVOPIRIDOLS, PROTEIN KINASE C, METALLOPROTEINASES, AND CYCLOOXYGENASE INHIBITORS FLAVOPIRIDOLS Cyclins; Flavopiridol-Induced Apoptosis; Inhibitors; PROTEIN KINASE C INHIBITORS A Bad Kinase; Inhibitors; METALLOPROTEINASE INHIBITORS Pathophysiology; Inhibitors
- CYCLOOXYGENASE INHIBITORS EicosanoidsNonsteroidal Anti-inflammatory Agents; RECENT DEVELOPMENTS IN MOLECULAR ONCOLOGY: PARTS I AND II; REFERENCES: PART II; PART III: ANTISENSE OLIGONUCLEOTIDES AND ANTI-ANGIOGENESIS ANTISENSE OLIGONUCLEOTIDES Viral Blockade; From Anti- to Pro-Apoptosis; c-myc; ANTI-NEOANGIOGENESIS Vasculogenesis; Angiogenesis; Inhibitors of Neoangiogenesis; Monoclonal Antibodies; Antisense Technology; Vaccines; REFERENCES, PART III; PART IV. THE PREDICTIVE VALUE OF TISSUE CULTURE AND XENOGRAFT ASSAYS CULTURE SHOCK Tissue Cultures; Trypsin
- THE TELOMERES ARE GETTING SHORTER TelomeraseRapamycins, As-ODN, Lymphocytes; ONE DAY IN THE LIFE OF ''IVAN XENOGRAFTOVICH''* Paracrine Circuits; Natural Killer Cells; Insulinlike Growth Factor-R; Activated Stroma; Intercellular Adhesions; Natural Hybridomas; THE MICROVASCULAR TUMOR BED Microvasculature; Suppressors; CHEMOKINE AND CYTOKINE GROWTH FACTORS Expropriated Cytokines; Matrix Metalloproteinases and Chemokines; Mesothelioma; Catenins, Caveolins, Connexins; Autocrine Circuits; Virus-Induced Cytokines and Chemokines
- HORMONE-RELATED EVENTS IN BREAST AND PROSTATE CANCERS Complex InteractionsAstonishing Observations; MISCELLANEOUS AGENTS TESTED IN XENOGRAFTS Xenografts of Human Tumors Are Very Sensitive to Noxious and Natural Substances; Endless List of Anti-Tumor Agents and Interventions; REFERENCES, PART IV; PART V: CLINICAL EXAMPLES: MULTIPLE MYELOMA AND GLIOBLASTOMA MULTIFORME MULTIPLE MYELOMA Pathogenesis; Biotherapy; GLIOBLASTOMA MULTIFORME Pathogenesis; Biotherapy; REFERENCES, PART V; DISCUSSION; SELECTED REFERENCES; SUMMARY
- Measles Virus: Improving Natural Oncolytic Properties by Genetic Engineering