Principles of translational science in medicine: from bench to bedside
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking...
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| Format: | Book/Monograph |
| Language: | English |
| Published: |
Burlington
Elsevier Science
2015
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| Edition: | 2nd ed |
| Subjects: | |
| Online Access: | Aggregator, lizenzpflichtig, Volltext: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=2007478
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| Author Notes: | edited by Martin Wehling |
Table of Contents:
- Front Cover; Principles of Translational Science in Medicine; Copyright; Contents; List of Contributors; Preface; Chapter 1 - Introduction and Definitions; WHAT IS TRANSLATIONAL MEDICINE?; PRIMARY TRANSLATION VERSUS SECONDARY TRANSLATION; THE HISTORY OF TRANSLATIONAL MEDICINE, OBSTACLES, AND REMITS; WHAT TRANSLATIONAL MEDICINE CAN AND CANNOT DO; THE PRESENT STATUS OF TRANSLATIONAL MEDICINE (INITIATIVES AND DEFICIENCIES); TRANSLATIONAL SCIENCE IN MEDICINE: THE CURRENT CHALLENGE; REFERENCES; Chapter 2 - Target Identification and Validation
- Chapter 2.1.1 - "Omics" Translation: A Challenge for Laboratory MedicineINTRODUCTION; "OMICS": WHAT DOES IT MEAN?; PROTEOMICS AS A PARADIGM OF PROBLEMS IN TRANSLATIONAL MEDICINE; DEVELOPMENT OF BIOMARKERS: FROM DISCOVERY TO CLINICAL APPLICATION; DISCOVERY; IDENTIFICATION/CHARACTERIZATION; VALIDATION; STANDARDIZATION/HARMONIZATION; CLINICAL ASSOCIATION AND CLINICAL BENEFIT; TRANSLATING OMICS INTO CLINICAL PRACTICE; CONTINUUM OF TRANSLATION RESEARCH AND OMICS; CONCLUSIONS; REFERENCES; Chapter 2.1.2 - "Omics" Technologies: Promises and Benefits for Molecular Medicine; INTRODUCTION; GENOMICS
- METABOLOMICSCONCLUSION; REFERENCES; Chapter 2.1.3 - Potency Analysis of Cellular Therapies: The Role of Molecular Assays; POTENCY TESTING; COMPLEXITIES ASSOCIATED WITH POTENCY TESTING OF CELLULAR THERAPIES; FACTORS AFFECTING THE POTENCY OF CELLULAR THERAPIES; MEASURING POTENCY OF CELLULAR THERAPIES; GENE EXPRESSION ARRAYS FOR POTENCY TESTING; POTENTIAL APPLICATIONS OF GENE EXPRESSION PROFILING FOR POTENCY TESTING; MICRORNAS AS POTENCY ASSAYS; CONCLUSIONS; REFERENCES; Chapter 2.1.4 - Translational Pharmacogenetics to Support Pharmacogenetically Driven Clinical Decision Making; INTRODUCTION
- PHARMACOGENETICS AS A TOOL FOR IMPROVING INDIVIDUAL DRUG THERAPYTYPES OF DRUG THERAPIES THAT MIGHT PROFIT FROM PHARMACOGENETIC DIAGNOSTICS; THE STATUS OF TRANSLATIONAL PHARMACOGENETICS IN VARIOUS DRUG THERAPY FIELDS; TRANSLATIONAL PHARMACOGENETICS AND THE NEED FOR CLINICAL STUDIES TO SUPPORT PHARMACOGENETICALLY DRIVEN PRESCRIBING; REFERENCES; Chapter 2.1.5 - Tissue Biobanks; INTRODUCTION; PRINCIPLES AND TYPES OF TISSUE BIOBANKS: PROS AND CONS; DEVELOPMENTS IN VASCULAR BIOBANKING RESEARCH AND CLINICAL RELEVANCE; CHALLENGES FOR FUTURE BIOBANKS; SUMMARY; REFERENCES
- Chapter 2.1.6 - Animal Models: Value and Translational PotencyWHAT IS THE VALUE OF ANIMAL MODELS? PATHOPHYSIOLOGICAL CONCEPTS; WHAT IS A GOOD ANIMAL MODEL FOR TRANSLATIONAL RESEARCH?; WHAT IS THE TRANSLATIONAL VALUE OF ANIMAL MODELS?; REMEDIES FOR FAILED TRANSLATION: IMPROVING PRECLINICAL RESEARCH; SUMMARY; REFERENCES; Chapter 2.1.7 - Localization Technologies and Immunoassays: Promises and Benefits for Molecular Medicine; INTRODUCTION; LOCALIZATION TECHNOLOGIES; IMMUNOASSAYS; CASE STUDY: SCREENING OF A BIOMARKER FOR KIDNEY INJURY USING LOCALIZATION AND IMMUNOASSAYS; REFERENCES
- Chapter 2.1.8 - Biomarkers in the Context of Health Authorities and Consortia