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Diphenylethyne Core
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Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier
by Abdallah, Mennatallah (Author)
, Hamed, Mostafa M. (Author)
, Frakolaki, Efseveia (Author)
, Katsamakas, Sotirios (Author)
, Vassilaki, Niki (Author)
, Bartenschlager, Ralf (Author)
, Zoidis, Grigoris (Author)
, Hirsch, Anna K. H. (Author)
, Abdel-Halim, Mohammad (Author)
, Abadi, Ashraf H. (Author)
,
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European journal of medicinal chemistry, 229 (2022), Artikel-ID 114034, Seite 1-20
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Klinikum der Universität Heidelberg
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Department für Infektiologie
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Abadi, Ashraf H.
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Abdallah, Mennatallah
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Abdel-Halim, Mohammad
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Bartenschlager, Ralf
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Frakolaki, Efseveia
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Hamed, Mostafa M.
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Hirsch, Anna K. H.
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Katsamakas, Sotirios
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Vassilaki, Niki
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Zoidis, Grigoris
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Cap conformation
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Diphenylethyne Core
Hepatitis C virus
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NS5A inhibitors
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Pan-genotypic activity
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Resistance mutations
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Spatial orientation
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