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Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trial by Loges, Sonja (Author) , Heuser, Michael (Author) , Chromik, Jörg (Author) , Sutamtewagul, Grerk (Author) , Kapp-Schwoerer, Silke (Author) , Crugnola, Monica (Author) , Di Renzo, Nicola (Author) , Lemoli, Roberto (Author) , Mattei, Daniele (Author) , Fiedler, Walter (Author) , Alvarado-Valero, Yesid (Author) , Ben-Batalla, Isabel (Author) , Waizenegger, Jonas (Author) , Rieckmann, Lisa-Marie (Author) , Janning, Melanie (Author) , Collienne, Maike (Author) , Imbusch, Charles (Author) , Beumer, Niklas (Author) , Micklem, David (Author) , Nilsson, Linn H. (Author) , Madeleine, Noëlly (Author) , McCracken, Nigel (Author) , Oliva, Cristina (Author) , Gorcea-Carson, Claudia (Author) , Gjertsen, Bjørn T. (Author) ,

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Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs by Gremke, Niklas (Author) , Besong, Isabelle (Author) , Stroh, Alina (Author) , von Wichert, Luise (Author) , Witt, Marie (Author) , Elmshäuser, Sabrina (Author) , Wanzel, Michael (Author) , Fromm, Martin F. (Author) , Taudte, R. Verena (Author) , Schmatloch, Sabine (Author) , Karn, Thomas (Author) , Reinisch, Mattea (Author) , Hirmas, Nader (Author) , Loibl, Sibylle (Author) , Wündisch, Thomas (Author) , Litmeyer, Anne-Sophie (Author) , Jank, Paul (Author) , Denkert, Carsten (Author) , Griewing, Sebastian (Author) , Wagner, Uwe (Author) , Stiewe, Thorsten (Author) ,

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Metabolomic reprogramming of the tumor microenvironment by dual arginase inhibitor OATD-02 boosts anticancer immunity by Grzybowski, Marcin Mikołaj (Author) , Uçal, Yasemin (Author) , Muchowicz, Angelika (Author) , Rejczak, Tomasz (Author) , Kikulska, Agnieszka (Author) , Głuchowska, Katarzyna Maria (Author) , Szostakowska-Rodzoś, Małgorzata (Author) , Zagożdżon, Agnieszka (Author) , Bausbacher, Tobias (Author) , Tkaczyk, Agnieszka (Author) , Kulma, Magdalena (Author) , Pomper, Paulina (Author) , Mlącki, Michał (Author) , Jagielski, Adam Konrad (Author) , Błaszczyk, Roman (Author) , Hopf, Carsten (Author) , Zasłona, Zbigniew (Author) ,

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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial by Kilburn, Lindsay B. (Author) , Khuong-Quang, Dong-Anh (Author) , Hansford, Jordan R. (Author) , Landi, Daniel (Author) , van der Lugt, Jasper (Author) , Leary, Sarah E. S. (Author) , Driever, Pablo Hernáiz (Author) , Bailey, Simon (Author) , Perreault, Sébastien (Author) , McCowage, Geoffrey (Author) , Waanders, Angela J. (Author) , Ziegler, David S. (Author) , Witt, Olaf (Author) , Baxter, Patricia A. (Author) , Kang, Hyoung Jin (Author) , Hassall, Timothy E. (Author) , Han, Jung Woo (Author) , Hargrave, Darren R. (Author) , Franson, Andrea T. (Author) , Yalon Oren, Michal (Author) , Toledano, Helen (Author) , Larouche, Valérie (Author) , Kline, Cassie (Author) , Abdelbaki, Mohamed S. (Author) , Jabado, Nada (Author) , Gottardo, Nicholas G. (Author) , Gerber, Nicolas U. (Author) , Whipple, Nicholas S. (Author) , Segal, Devorah (Author) , Chi, Susan N. (Author) , Oren, Liat (Author) , Tan, Enrica E. K. (Author) , Müller, Sabine (Author) , Cornelio, Izzy (Author) , McLeod, Lisa (Author) , Zhao, Xin (Author) , Walter, Ashley (Author) , Da Costa, Daniel (Author) , Manley, Peter (Author) , Blackman, Samuel C. (Author) , Packer, Roger J. (Author) , Nysom, Karsten (Author) ,

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Special FDA designations for drug development: orphan, fast track, accelerated approval, priority review, and breakthrough therapy by Michaeli, Daniel (Author) , Michaeli, Christoph T. (Author) , Albers, Sebastian (Author) , Boch, Tobias (Author) , Michaeli, Julia (Author) ,

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Next-generation study databases require FAIR, EHR-integrated, and scalable Electronic Data Capture for medical documentation and decision support by Dugas, Martin (Author) , Blumenstock, Max (Author) , Dittrich, Tobias (Author) , Eisenmann, Urs (Author) , Feder, Stephan Christoph (Author) , Fritz-Kebede, Fleur (Author) , Kessler, Lucy Joanne (Author) , Klass, Maximilian (Author) , Knaup-Gregori, Petra (Author) , Lehmann, Christoph U. (Author) , Merzweiler, Angela (Author) , Niklas, Christian (Author) , Pausch, Thomas (Author) , Zental, Nelly (Author) , Ganzinger, Matthias (Author) ,

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Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV by Ramon, Aubin (Author) , Ali, Montader (Author) , Atkinson, Misha (Author) , Saturnino, Alessio (Author) , Didi, Kieran (Author) , Visentin, Cristina (Author) , Ricagno, Stefano (Author) , Xu, Xing (Author) , Greenig, Matthew (Author) , Sormanni, Pietro (Author) ,

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How to develop new systemic treatments in ultra-rare cancers with high unmet needs?: The case of alveolar soft-part sarcoma by Stacchiotti, Silvia (Author) , Bouche, Gauthier (Author) , Herold, Ralf (Author) , Pantziarka, Pan (Author) , Schuster, Kathrin (Author) , Wilson, Roger (Author) , Pignatti, Francesco (Author) , Kasper, Bernd (Author) ,

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Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs) by Schmitt, Laura (Author) , Hoppe, Julia (Author) , Cea-Medina, Pablo (Author) , Bruch, Peter-Martin (Author) , Krings, Karina S. (Author) , Lechtenberg, Ilka (Author) , Drießen, Daniel (Author) , Peter, Christoph (Author) , Bhatia, Sanil (Author) , Dietrich, Sascha (Author) , Stork, Björn (Author) , Fritz, Gerhard (Author) , Gohlke, Holger (Author) , Müller, Thomas J. J. (Author) , Wesselborg, Sebastian (Author) ,

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Cytotoxicity of dioncophylline A and related naphthylisoquinolines in leukemia cells, mediated by NF-κB inhibition, angiogenesis suppression, G2/M cell cycle arrest, and autophagy... by Yücer, Rümeysa (Author) , Fayez, Shaimaa (Author) , Feineis, Doris (Author) , Klauck, Sabine (Author) , Shan, Letian (Author) , Bringmann, Gerhard (Author) , Efferth, Thomas (Author) , Dawood, Mona (Author) ,

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Advancing ASO therapies from development to implementation by Schüle-Freyer, Rebecca (Author) , Synofzik, Matthis (Author) , Graessner, Holm (Author) , Aartsma-Rus, Annemieke (Author) ,

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Seratrodast inhibits ferroptosis by suppressing lipid peroxidation by Tschuck, Juliane (Author) , Tonnus, Wulf (Author) , Gavali, Shubhangi (Author) , Kolak, Andrea (Author) , Mallais, Melodie (Author) , Maremonti, Francesca (Author) , Sato, Mami (Author) , Rothenaigner, Ina (Author) , Friedmann Angeli, José Pedro (Author) , Pratt, Derek A. (Author) , Linkermann, Andreas Günter (Author) , Hadian, Kamyar (Author) ,

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Treosulfan vs busulfan conditioning for allogeneic bmt in children with nonmalignant disease: a randomized phase 2 trial by Sykora, Karl-Walter (Author) , Beier, Rita (Author) , Schulz, Ansgar Stephan (Author) , Cesaro, Simone (Author) , Greil, Johann (Author) , Gozdzik, Jolanta (Author) , Sedlácek, Petr (Author) , Bader, Peter (Author) , Schulte, Johannes (Author) , Zecca, Marco (Author) , Locatelli, Franco (Author) , Gruhn, Bernd (Author) , Reinhardt, Dirk (Author) , Styczyński, Jan (Author) , Piras, Simona (Author) , Fagioli, Franca (Author) , Bonanomi, Sonia (Author) , Caniglia, Maurizio (Author) , Li, Xieran (Author) , Baumgart, Joachim (Author) , Kehne, Jochen (Author) , Mielcarek-Siedziuk, Monika (Author) , Kalwak, Krzysztof (Author) ,

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Translatability scoring in prospective and retrospective COVID drug development cases: research by Wendler, Alexandra (Author) , Wehling, Martin (Author) ,

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Correcting the drug development paradigm for glioblastoma requires serial tissue sampling by Singh, Kirit (Author) , Hotchkiss, Kelly M. (Author) , Parney, Ian F. (Author) , De Groot, John (Author) , Sahebjam, Solmaz (Author) , Sanai, Nader (Author) , Platten, Michael (Author) , Galanis, Evanthia (Author) , Lim, Michael (Author) , Wen, Patrick Y. (Author) , Minniti, Giuseppe (Author) , Colman, Howard (Author) , Cloughesy, Timothy F. (Author) , Mehta, Minesh P. (Author) , Geurts, Marjolein (Author) , Arrillaga-Romany, Isabel (Author) , Desjardins, Annick (Author) , Tanner, Kirk (Author) , Short, Susan (Author) , Arons, David (Author) , Duke, Elizabeth (Author) , Wick, Wolfgang (Author) , Bagley, Stephen J. (Author) , Ashley, David M. (Author) , Kumthekar, Priya (Author) , Verhaak, Roel (Author) , Chalmers, Anthony J. (Author) , Patel, Anoop P. (Author) , Watts, Colin (Author) , Fecci, Peter E. (Author) , Batchelor, Tracy T. (Author) , Weller, Michael (Author) , Vogelbaum, Michael A. (Author) , Preusser, Matthias (Author) , Berger, Mitchel S. (Author) , Khasraw, Mustafa (Author) ,

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Orphan drug development in alpha-1 antitypsin deficiency by Trudzinski, Franziska (Author) , Presotto, Maria Ada (Author) , Buck, Emanuel (Author) , Herth, Felix (Author) , Ries, Markus (Author) ,

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Value drivers of development stage biopharma companies by Michaeli, Daniel (Author) , Yagmur, Hasan Basri (Author) , Achmadeev, Timur (Author) , Michaeli, Christoph T. (Author) ,

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Addressing artifacts of colorimetric anticancer assays for plant-based drug development by Batool, Salma (Author) , Javaid, Seejal (Author) , Javed, Hira (Author) , Asim, Laiba (Author) , Shahid, Izzah (Author) , Khan, Mishal (Author) , Muhammad, Amna (Author) ,

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Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency w... by Pearson, Andrew D. J. (Author) , Allen, Carl (Author) , Fangusaro, Jason (Author) , Hutter, Caroline (Author) , Witt, Olaf (Author) , Weiner, Susan (Author) , Reaman, Gregory (Author) , Russo, Mark (Author) , Bandopadhayay, Pratiti (Author) , Ahsan, Sama (Author) , Barone, Amy (Author) , Barry, Elly (Author) , de Rojas, Teresa (Author) , Fisher, Michael (Author) , Fox, Elizabeth (Author) , Bender, Julia Glade (Author) , Gore, Lia (Author) , Hargrave, Darren (Author) , Hawkins, Doug (Author) , Kreider, Brent (Author) , Langseth, Abraham J. (Author) , Lesa, Giovanni (Author) , Ligas, Franca (Author) , Marotti, Marcelo (Author) , Marshall, Lynley V. (Author) , Nasri, Kahina (Author) , Norga, Koen (Author) , Nysom, Karsten (Author) , Pappo, Alberto (Author) , Rossato, Gianluca (Author) , Scobie, Nicole (Author) , Smith, Malcolm (Author) , Stieglitz, Elliot (Author) , Weigel, Brenda (Author) , Weinstein, Amy (Author) , Viana, Ruth (Author) , Karres, Dominik (Author) , Vassal, Gilles (Author) ,

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Initial and supplementary indication approval of new targeted cancer drugs by the FDA, EMA, Health Canada, and TGA: phase III studies by Michaeli, Daniel (Author) , Mills, Mackenzie (Author) , Michaeli, Christoph T. (Author) , Miracolo, Aurelio (Author) , Kanavos, Panos (Author) ,

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