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non-competitive inhibition
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A mechanistic, enantioselective, physiologically based pharmacokinetic model of verapamil and norverapamil, built and evaluated for drug-drug interaction studies
by Hanke, Nina (Author)
, Türk, Denise (Author)
, Selzer, Dominik (Author)
, Wiebe, Sabrina (Author)
, Fernandez, Éric (Author)
, Stopfer, Peter (Author)
, Nock, Valerie Christine (Author)
, Lehr, Thorsten (Author)
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Pharmaceutics, 12 (2020,6) Artikel-Nummer 556, 19 Seiten
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Medizinische Fakultät Heidelberg
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Fernandez, Éric
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Hanke, Nina
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Lehr, Thorsten
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Nock, Valerie Christine
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Selzer, Dominik
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Stopfer, Peter
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P-glycoprotein (Pgp)
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cytochrome P450 3A4 (CYP3A4)
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drug-drug interactions (DDIs)
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mechanism-based inactivation (MBI)
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model-informed drug discovery and development (MID3)
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non-competitive inhibition
norverapamil
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physiologically based pharmacokinetic (PBPK) modeling
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verapamil
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