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TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS
by Yan, Jing (Author)
, Wang, Yumeng (Author)
, Hellwig, Andrea (Author)
, Bading, Hilmar (Author)
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Cell reports. Medicine, 5 (2024), 2, Artikel-ID 101413, Seite 1-9
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TwinF interface inhibitor FP802 prevents retinal ganglion cell loss in a mouse model of amyotrophic lateral sclerosis
by Wang, Yumeng (Author)
, Yan, Jing (Author)
, Williams-Fairless, Sarah K. (Author)
, Fairless, Richard (Author)
, Bading, Hilmar (Author)
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Acta Neuropathologica Communications, 12 (2024), 1, Artikel-ID 149, Seite 1-9
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Interdisziplinäres Zentrum für Neurowissenschaften (IZN)
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IZN Neurobiologie
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Klinikum der Universität Heidelberg
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Neurologische Universitätsklinik
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Bading, Hilmar
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Wang, Yumeng
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Yan, Jing
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Fairless, Richard
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Hellwig, Andrea
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Williams-Fairless, Sarah K.
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FP802
TwinF interface inhibitor
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Amyotrophic lateral sclerosis
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NMDAR/TRPM4 death signaling complex
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Neuroprotection
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Neuroprotective gene regulation
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Retinal ganglion cell degeneration
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amyotrophic lateral sclerosis
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biomarker
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excitotoxicity
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extrasynaptic NMDA receptor
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gene expression
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glutamate neurotoxicity
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neuroprotection
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