Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2
Fibroblast growth factor (FGF)-2 is an abundant astroglial cytokine. We have previously shown that FGF-2 downregulates gap junctions in primary astroglial cultures (B. Reuss et al., 1998, Glia 22, 19-30). We demonstrate now that FGF-2 induces astroglial dopamine (DA) sensitivity and D1 dopamine-rece...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 May 2002
|
| In: |
Molecular and cellular neuroscience
Year: 2000, Volume: 16, Issue: 1, Pages: 42-58 |
| ISSN: | 1095-9327 |
| DOI: | 10.1006/mcne.2000.0857 |
| Online Access: | Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1044743100908571 Verlag, Volltext: http://dx.doi.org/10.1006/mcne.2000.0857 
|
| Author Notes: | Bernhard Reuss, Doreen S.Y. Leung, Carsten Ohlemeyer, Helmut Kettenmann, and Klaus Unsicker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 155012238X | ||
| 003 | DE-627 | ||
| 005 | 20220813092057.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 161124r20022000xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1006/mcne.2000.0857 |2 doi | |
| 035 | |a (DE-627)155012238X | ||
| 035 | |a (DE-576)480122385 | ||
| 035 | |a (DE-599)BSZ480122385 | ||
| 035 | |a (OCoLC)1340939712 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Reuss, Bernhard |d 1965- |e VerfasserIn |0 (DE-588)17291454X |0 (DE-627)697842266 |0 (DE-576)133769216 |4 aut | |
| 245 | 1 | 0 | |a Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2 |c Bernhard Reuss, Doreen S.Y. Leung, Carsten Ohlemeyer, Helmut Kettenmann, and Klaus Unsicker |
| 264 | 1 | |c 25 May 2002 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.11.2016 | ||
| 520 | |a Fibroblast growth factor (FGF)-2 is an abundant astroglial cytokine. We have previously shown that FGF-2 downregulates gap junctions in primary astroglial cultures (B. Reuss et al., 1998, Glia 22, 19-30). We demonstrate now that FGF-2 induces astroglial dopamine (DA) sensitivity and D1 dopamine-receptor (D1DR) antigen and message in cortical and striatal astroglial cultures. On the functional level 10 μmol/L DA triggered transient increases in astroglial [Ca2+]i. In gap-junction-coupled cells, no FGF-2-dependent changes in proportions of DA-responsive cells were observable. However, uncoupling with octanol or 18α-glycirrhetinic acid isolated the smaller population of astrocytes intrinsically sensitive to DA which was significantly increased by FGF-2 in cortical and striatal cultures. Administration of DR-specific substances revealed that FGF-2 upregulated D1DR. These results indicate that downregulation of astroglial gap junctions by FGF-2 is accompanied by an upregulation of D1DR and DA sensitivity, adding a new aspect to the role of FGF-2 in the regulation of brain functions. | ||
| 534 | |c 2000 | ||
| 700 | 1 | |a Leung, Doreen Siu Yi |e VerfasserIn |0 (DE-588)1095889478 |0 (DE-627)856457876 |0 (DE-576)467838488 |4 aut | |
| 700 | 1 | |a Unsicker, Klaus |d 1942- |e VerfasserIn |0 (DE-588)106365614 |0 (DE-627)503360635 |0 (DE-576)289555515 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular and cellular neuroscience |d San Diego, Calif. : Elsevier, 1990 |g 16(2000), 1, Seite 42-58 |h Online-Ressource |w (DE-627)267840330 |w (DE-600)1471177-1 |w (DE-576)097188573 |x 1095-9327 |7 nnas |a Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2 |
| 773 | 1 | 8 | |g volume:16 |g year:2000 |g number:1 |g pages:42-58 |g extent:17 |a Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2 |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1044743100908571 |x Verlag |3 Volltext |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1006/mcne.2000.0857 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20161125 | ||
| 993 | |a Article | ||
| 994 | |a 2000 | ||
| 998 | |g 106365614 |a Unsicker, Klaus |m 106365614:Unsicker, Klaus |d 50000 |d 53100 |e 50000PU106365614 |e 53100PU106365614 |k 0/50000/ |k 1/50000/53100/ |p 5 |y j | ||
| 998 | |g 1095889478 |a Leung, Doreen Siu Yi |m 1095889478:Leung, Doreen Siu Yi |d 50000 |d 53100 |e 50000PL1095889478 |e 53100PL1095889478 |k 0/50000/ |k 1/50000/53100/ |p 2 | ||
| 998 | |g 17291454X |a Reuss, Bernhard |m 17291454X:Reuss, Bernhard |d 50000 |d 53100 |e 50000PR17291454X |e 53100PR17291454X |k 0/50000/ |k 1/50000/53100/ |p 1 |x j | ||
| 999 | |a KXP-PPN155012238X |e 2946375439 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Bernhard","role":"aut","display":"Reuss, Bernhard","family":"Reuss"},{"given":"Doreen Siu Yi","role":"aut","family":"Leung","display":"Leung, Doreen Siu Yi"},{"role":"aut","given":"Klaus","display":"Unsicker, Klaus","family":"Unsicker"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 24.11.2016"],"origin":[{"dateIssuedKey":"2002","dateIssuedDisp":"25 May 2002"}],"title":[{"title":"Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2","title_sort":"Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2"}],"recId":"155012238X","physDesc":[{"extent":"17 S."}],"name":{"displayForm":["Bernhard Reuss, Doreen S.Y. Leung, Carsten Ohlemeyer, Helmut Kettenmann, and Klaus Unsicker"]},"id":{"eki":["155012238X"],"doi":["10.1006/mcne.2000.0857"]},"relHost":[{"language":["eng"],"note":["Gesehen am 20.02.20"],"origin":[{"publisherPlace":"San Diego, Calif. ; Orlando, Fla.","dateIssuedDisp":"1990-","dateIssuedKey":"1990","publisher":"Elsevier ; Academic Press"}],"titleAlt":[{"title":"MCN"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Molecular and cellular neuroscience","subtitle":"MCN","title_sort":"Molecular and cellular neuroscience"}],"part":{"volume":"16","extent":"17","text":"16(2000), 1, Seite 42-58","pages":"42-58","year":"2000","issue":"1"},"disp":"Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2Molecular and cellular neuroscience","id":{"issn":["1095-9327"],"eki":["267840330"],"zdb":["1471177-1"]},"pubHistory":["1.1990 -"],"recId":"267840330","physDesc":[{"extent":"Online-Ressource"}]}]} | ||
| SRT | |a REUSSBERNHREGIONALLY2520 | ||