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Control of diabetic hyperglycaemia and insulin resistance through TSC22D4

TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13...

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Main Authors: Üstünel, Bilgen Ekim (Author) , Friedrich, Kilian (Author) , Sticht, Carsten (Author) , Gretz, Norbert (Author) , Fleming, Thomas (Author) , Nawroth, Peter Paul (Author) , Stremmel, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 09 November 2016
In: Nature Communications
Year: 2016, Volume: 7, Pages: 1-11
ISSN:2041-1723
DOI:10.1038/ncomms13267
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms13267
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pubmed/27827363
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Author Notes:Bilgen Ekim Üstünel, Kilian Friedrich, Adriano Maida, Xiaoyue Wang, Anja Krones-Herzig, Oksana Seibert, Anke Sommerfeld, Allan Jones, Tjeerd P. Sijmonsma, Carsten Sticht, Norbert Gretz, Thomas Fleming, Peter P. Nawroth, Wolfgang Stremmel, Adam J. Rose, Mauricio Berriel-Diaz, Matthias Blüher & Stephan Herzig
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Summary:TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13.
Item Description:Gesehen am 12.01.2017
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms13267

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