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Control of diabetic hyperglycaemia and insulin resistance through TSC22D4

TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13...

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Bibliographische Detailangaben
Hauptverfasser: Üstünel, Bilgen Ekim (VerfasserIn) , Friedrich, Kilian (VerfasserIn) , Sticht, Carsten (VerfasserIn) , Gretz, Norbert (VerfasserIn) , Fleming, Thomas (VerfasserIn) , Nawroth, Peter Paul (VerfasserIn) , Stremmel, Wolfgang (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 09 November 2016
In: Nature Communications
Year: 2016, Jahrgang: 7, Pages: 1-11
ISSN:2041-1723
DOI:10.1038/ncomms13267
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms13267
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pubmed/27827363
Volltext
Verfasserangaben:Bilgen Ekim Üstünel, Kilian Friedrich, Adriano Maida, Xiaoyue Wang, Anja Krones-Herzig, Oksana Seibert, Anke Sommerfeld, Allan Jones, Tjeerd P. Sijmonsma, Carsten Sticht, Norbert Gretz, Thomas Fleming, Peter P. Nawroth, Wolfgang Stremmel, Adam J. Rose, Mauricio Berriel-Diaz, Matthias Blüher & Stephan Herzig
Beschreibung
Zusammenfassung:TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13.
Beschreibung:Gesehen am 12.01.2017
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms13267

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