Fate restriction and multipotency in retinal stem cells
Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the f...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 1, 2011
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| In: |
Cell stem cell
Year: 2011, Volume: 9, Issue: 6, Pages: 553-562 |
| ISSN: | 1875-9777 |
| DOI: | 10.1016/j.stem.2011.11.004 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.stem.2011.11.004 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1934590911005327 
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| Author Notes: | Lázaro Centanin, Burkhard Hoeckendorf, and Joachim Wittbrodt |
| Summary: | Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and follow the complete offspring of a single cell during the postnatal life. RSCs generate two tissues of the adult fish retina, the neural retina (NR) and the retinal-pigmented epithelium (RPE). Despite their common embryonic origin and tight coordination during continuous organ growth, we prove that NR and RPE are maintained by dedicated RSCs that contribute in a fate-restricted manner to either one or the other tissue. We show that in the NR, RSCs are multipotent and generate all neuron types and glia. The clonal origin of these different cell types from a multipotent NSC has far-reaching implications for cell type and tissue homeostasis. |
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| Item Description: | Gesehen am 13.02.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1875-9777 |
| DOI: | 10.1016/j.stem.2011.11.004 |