Signaling pathways and axis formation in the lower metazoa
The determination of the body axis in the last common ancestor of bilaterian animals is still a matter of debate. While Hox genes pattern the formation of the primary, anteroposterior body axis in bilaterians, there is growing evidence from lower metazoans that the Wnt/β-catenin pathway acts as the...
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| Main Authors: | , , |
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| Format: | Chapter/Article |
| Language: | English |
| Published: |
2011
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| In: |
Growth factors in development
Year: 2011, Pages: 137-177 |
| DOI: | 10.1016/B978-0-12-385975-4.00012-7 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/B978-0-12-385975-4.00012-7 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/B9780123859754000127 
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| Author Notes: | Thomas W. Holstein, Hiroshi Watanabe, Suat Özbek |
| Summary: | The determination of the body axis in the last common ancestor of bilaterian animals is still a matter of debate. While Hox genes pattern the formation of the primary, anteroposterior body axis in bilaterians, there is growing evidence from lower metazoans that the Wnt/β-catenin pathway acts as the primordial signaling system in this process. This review summarizes molecular data from recent genomic analyses of basal model organisms with a focus on the evolution of signaling pathways involved in the establishment of the primary and successive body axes during early metazoan evolution. |
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| Item Description: | Gesehen am 16.02.2017 |
| Physical Description: | Online Resource |
| ISBN: | 9780123859754 0123859751 9780123859761 012385976X |
| DOI: | 10.1016/B978-0-12-385975-4.00012-7 |