Risk factors for retinopathy and DME in type 2 diabetes: results from the German/Austrian DPV database
To assess the prevalence and risk factors for early and severe diabetic retinopathy and macular edema in a large cohort of patients with type 2 diabetes Retinopathy grading (any retinopathy, severe retinopathy, diabetic macular edema) and risk factors of 64784 were prospectively recorded between Jan...
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 July 2015
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| In: |
PLOS ONE
Year: 2015, Volume: 10, Issue: 7 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0132492 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0132492 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132492 
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| Author Notes: | Hans-Peter Hammes, Reinhard Welp, Hans-Peter Kempe, Christian Wagner, Erhard Siegel, Reinhard W. Holl, DPV Initiative-German BMBF Competence Network Diabetes Mellitus |
| Summary: | To assess the prevalence and risk factors for early and severe diabetic retinopathy and macular edema in a large cohort of patients with type 2 diabetes Retinopathy grading (any retinopathy, severe retinopathy, diabetic macular edema) and risk factors of 64784 were prospectively recorded between January 2000 and March 2013 and analyzed by Kaplan-Meier analysis and logistic regression. Retinopathy was present in 20.12% of subjects, maculopathy was found in 0.77%. HbA1c > 8%, microalbuminuria, hypertension, BMI > 35 kg/m2 and male sex were significantly associated with any retinopathy, while HbA1c and micro- and macroalbuminuria were the strongest risk predictors for severe retinopathy. Presence of macroalbuminuria increased the risk for DME by 177%. Retinopathy remains a significant clinical problem in patients with type 2 diabetes. Metabolic control and blood pressure are relevant factors amenable to treatment. Concomitant kidney disease identifies high risk patients and should be emphasized in interdisciplinary communication. |
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| Item Description: | Gesehen am 23.02.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0132492 |