Comparison of gadofosveset (Vasovist®) with gadobenate dimeglumine (Multihance®)-enhanced MR angiography for high-grade carotid artery stenosis
Summary: Objective To prove superiority of blood pool contrast agent gadofosveset over conventional contrast agent gadobenate dimeglumine for assessment of stenotic internal carotid artery (ICA). Methods: Eleven patients with high-grade ICA stenosis (≥ 75%), confirmed by duplex sonography, underwent...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2015
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| In: |
Journal of neuroradiology
Year: 2015, Volume: 42, Issue: 4, Pages: 236-244 |
| ISSN: | 1773-0406 |
| DOI: | 10.1016/j.neurad.2014.03.002 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.neurad.2014.03.002 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S0150986114001825 
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| Author Notes: | E. Amarteifio, M. Essig, D. Böckler, N. Attigah, L. Schuster, S. Demirel |
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| 520 | |a Summary: Objective To prove superiority of blood pool contrast agent gadofosveset over conventional contrast agent gadobenate dimeglumine for assessment of stenotic internal carotid artery (ICA). Methods: Eleven patients with high-grade ICA stenosis (≥ 75%), confirmed by duplex sonography, underwent MR angiography (MRA) with gadofosveset and gadobenate dimeglumine. Results: Agreement in stenosis grade was reached in 7 of 10 stenotic ICAs. In two ICAs, gadobenate dimeglumine led to underestimation of stenosis grade. There was a significant difference in signal intensity (pre-/post-stenotic segments), showing higher values for gadofosveset (P < 0.01; P < 0.05). Impression of contrast intensity with gadofosveset was better in 8 ICAs and only in 1 ICA with gadobenate dimeglumine (P < 0.05). Conclusion: Gadofosveset-enhanced MR angiography may be superior for assessment of high-grade ICA stenosis compared with gadobenate dimeglumine MR angiography. | ||
| 650 | 4 | |a Carotid artery stenosis | |
| 650 | 4 | |a Gadobenate dimeglumine | |
| 650 | 4 | |a Gadofosveset | |
| 650 | 4 | |a Magnetic resonance imaging | |
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