Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro
CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HB...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 July 2015
|
| In: |
Journal of virology
Year: 2015, Volume: 89, Issue: 14, Pages: 7433-7438 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.00605-15 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1128/JVI.00605-15 Verlag, kostenfrei, Volltext: https://journals.asm.org/doi/10.1128/jvi.00605-15 
|
| Author Notes: | Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1556246706 | ||
| 003 | DE-627 | ||
| 005 | 20240930133207.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170404s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/JVI.00605-15 |2 doi | |
| 035 | |a (DE-627)1556246706 | ||
| 035 | |a (DE-576)486246701 | ||
| 035 | |a (DE-599)BSZ486246701 | ||
| 035 | |a (OCoLC)1340972622 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hoh, Alexander |e VerfasserIn |0 (DE-588)1024952711 |0 (DE-627)720811961 |0 (DE-576)369725476 |4 aut | |
| 245 | 1 | 0 | |a Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro |c Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
| 246 | 3 | 3 | |a Hepatitis B virus-infected HepG2 hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8 + T cells in vitro |
| 264 | 1 | |c 15 July 2015 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist „hNTCP“ und "+"hochgestellt | ||
| 500 | |a Gesehen am 04.04.2017 | ||
| 520 | |a CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads. | ||
| 700 | 1 | |a Urban, Stephan |e VerfasserIn |0 (DE-588)1060263599 |0 (DE-627)79935399X |0 (DE-576)174162049 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of virology |d Baltimore, Md. : Soc., 1967 |g 89(2015), 14, Seite 7433-7438 |h Online-Ressource |w (DE-627)303614609 |w (DE-600)1495529-5 |w (DE-576)08088766X |x 1098-5514 |7 nnas |a Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro |
| 773 | 1 | 8 | |g volume:89 |g year:2015 |g number:14 |g pages:7433-7438 |g extent:6 |a Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1128/JVI.00605-15 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://journals.asm.org/doi/10.1128/jvi.00605-15 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170404 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1060263599 |a Urban, Stephan |m 1060263599:Urban, Stephan |d 910000 |d 911700 |e 910000PU1060263599 |e 911700PU1060263599 |k 0/910000/ |k 1/910000/911700/ |p 11 | ||
| 999 | |a KXP-PPN1556246706 |e 2963863918 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Im Titel ist „hNTCP“ und \"+\"hochgestellt","Gesehen am 04.04.2017"],"titleAlt":[{"title":"Hepatitis B virus-infected HepG2 hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8 + T cells in vitro"}],"relHost":[{"title":[{"title_sort":"Journal of virology","title":"Journal of virology","subtitle":"publ. by the American Society for Microbiology"}],"language":["eng"],"pubHistory":["1.1967 -"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"role":"isb","display":"American Society for Microbiology"}],"note":["Gesehen am 13.12.2021"],"part":{"issue":"14","year":"2015","text":"89(2015), 14, Seite 7433-7438","extent":"6","pages":"7433-7438","volume":"89"},"id":{"issn":["1098-5514"],"zdb":["1495529-5"],"eki":["303614609"]},"origin":[{"publisherPlace":"Baltimore, Md.","publisher":"Soc.","dateIssuedKey":"1967","dateIssuedDisp":"1967-"}],"disp":"Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitroJournal of virology","recId":"303614609"}],"person":[{"given":"Alexander","role":"aut","family":"Hoh","display":"Hoh, Alexander"},{"given":"Stephan","role":"aut","family":"Urban","display":"Urban, Stephan"}],"title":[{"title_sort":"Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro","title":"Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro"}],"physDesc":[{"extent":"6 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1128/JVI.00605-15"],"eki":["1556246706"]},"origin":[{"dateIssuedDisp":"15 July 2015","dateIssuedKey":"2015"}],"name":{"displayForm":["Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme"]},"recId":"1556246706"} | ||
| SRT | |a HOHALEXANDHEPATITISB1520 | ||