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A peptide-gated ion channel from the freshwater polyp Hydra

Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na+ channel (FaNaC) from snails. Until now FaNaC has been regarded...

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Bibliographische Detailangaben
Hauptverfasser: Golubovic, Andjelko (VerfasserIn) , Kuhn, Anne (VerfasserIn) , Holstein, Thomas W. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 2, 2007
In: The journal of biological chemistry
Year: 2007, Jahrgang: 282, Heft: 48, Pages: 35098-35103
ISSN:1083-351X
DOI:10.1074/jbc.M706849200
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1074/jbc.M706849200
Verlag, kostenfrei, Volltext: http://www.jbc.org/content/282/48/35098
Volltext
Verfasserangaben:Andjelko Golubovic, Anne Kuhn, Michael Williamson, Hubert Kalbacher, Thomas W. Holstein, Cornelis J.P. Grimmelikhuijzen, and Stefan Gründer
Beschreibung
Zusammenfassung:Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na+ channel (FaNaC) from snails. Until now FaNaC has been regarded as a curiosity, and it was not known whether peptide-gated ionotropic receptors are also present in other animal groups. Nervous systems first evolved in cnidarians, which extensively use neuropeptides. Here we report cloning from the freshwater cnidarian Hydra of a novel ion channel (Hydra sodium channel, HyNaC) that is directly gated by the neuropeptides Hydra-RFamides I and II and is related to FaNaC. The cells expressing HyNaC localize to the base of the tentacles, adjacent to the neurons producing the Hydra-RFamides, suggesting that the peptides are the natural ligands for this channel. Our results suggest that neuropeptides were already used for fast transmission in ancient nervous systems.
Beschreibung:Gesehen am 08.05.2017
Beschreibung:Online Resource
ISSN:1083-351X
DOI:10.1074/jbc.M706849200

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