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A peptide-gated ion channel from the freshwater polyp Hydra

Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na+ channel (FaNaC) from snails. Until now FaNaC has been regarded...

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Bibliographic Details
Main Authors: Golubovic, Andjelko (Author) , Kuhn, Anne (Author) , Holstein, Thomas W. (Author)
Format: Article (Journal)
Language:English
Published: October 2, 2007
In: The journal of biological chemistry
Year: 2007, Volume: 282, Issue: 48, Pages: 35098-35103
ISSN:1083-351X
DOI:10.1074/jbc.M706849200
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1074/jbc.M706849200
Verlag, kostenfrei, Volltext: http://www.jbc.org/content/282/48/35098
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Author Notes:Andjelko Golubovic, Anne Kuhn, Michael Williamson, Hubert Kalbacher, Thomas W. Holstein, Cornelis J.P. Grimmelikhuijzen, and Stefan Gründer
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Summary:Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na+ channel (FaNaC) from snails. Until now FaNaC has been regarded as a curiosity, and it was not known whether peptide-gated ionotropic receptors are also present in other animal groups. Nervous systems first evolved in cnidarians, which extensively use neuropeptides. Here we report cloning from the freshwater cnidarian Hydra of a novel ion channel (Hydra sodium channel, HyNaC) that is directly gated by the neuropeptides Hydra-RFamides I and II and is related to FaNaC. The cells expressing HyNaC localize to the base of the tentacles, adjacent to the neurons producing the Hydra-RFamides, suggesting that the peptides are the natural ligands for this channel. Our results suggest that neuropeptides were already used for fast transmission in ancient nervous systems.
Item Description:Gesehen am 08.05.2017
Physical Description:Online Resource
ISSN:1083-351X
DOI:10.1074/jbc.M706849200

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