Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland
Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 September 1993
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| In: |
Nature
Year: 1993, Volume: 365, Issue: 6444, Pages: 314-320 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/365314a0 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/365314a0 Verlag, Volltext: https://www.nature.com/nature/journal/v365/n6444/abs/365314a0.html 
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| Author Notes: | Jörg H. Stehle, Nicholas S. Foulkes, Carlos A. Molina, Valérie Simonneaux, Paul Pévet & Paolo Sassone-Corsi |
| Summary: | Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway. |
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| Item Description: | Gesehen am 12.05.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/365314a0 |