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Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice

Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. Recently, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in...

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Main Authors: Fritzsching, Benedikt (Author) , Hagner, Matthias (Author) , Christochowitz, Sandra (Author) , Agrawal, Raman (Author) , Bodegom, Charlotte van (Author) , Schatterny, Jolanthe (Author) , Hirtz, Stephanie (Author) , Brown, Ryan (Author) , Dürr, Julia (Author) , Zhou-Suckow, Zhe (Author) , Mall, Marcus A. (Author)
Format: Article (Journal)
Language:English
Published: July 2017
In: The journal of allergy and clinical immunology
Year: 2017, Volume: 140, Issue: 1, Pages: 190-203.e5
ISSN:1097-6825
DOI:10.1016/j.jaci.2016.09.045
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.jaci.2016.09.045
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0091674916312969
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Author Notes:Benedikt Fritzsching, Matthias Hagner, Lu Dai, Sandra Christochowitz, Raman Agrawal, Charlotte van Bodegom, Simone Schmidt, Jolanthe Schatterny, Stephanie Hirtz, Ryan Brown, Michelle Goritzka, Julia Duerr, Zhe Zhou-Suckow, and Marcus A. Mall
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Summary:Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. Recently, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in juvenile β-epithelial Na+ channel (Scnn1b)-transgenic (Tg) mice.
Item Description:Gesehen am 03.07.2017
Physical Description:Online Resource
ISSN:1097-6825
DOI:10.1016/j.jaci.2016.09.045

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