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Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons

Background:Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl− accumulation in sensory endings establishes the driving force for depolarizing, and even excitatory, Cl− currents. The intracellular Cl− concentration can, ho...

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Bibliographic Details
Main Authors: Lehmeyer-Funk, Katharina (Author) , Woitecki, Anne (Author) , Franjic-Würtz, Christina (Author) , Möhrlen, Frank (Author) , Frings, Stephan (Author)
Format: Article (Journal)
Language:English
Published: 12 August 2008
In: Molecular pain
Year: 2008, Volume: 4, Pages: 1-12
ISSN:1744-8069
DOI:10.1186/1744-8069-4-32
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1744-8069-4-32
Verlag, kostenfrei, Volltext: http://journals.sagepub.com/doi/10.1186/1744-8069-4-32
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Author Notes:Katharina Funk, Anne Woitecki, Christina Franjic-Würtz, Thomas Gensch, Frank Möhrlen and Stephan Frings
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Summary:Background:Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl− accumulation in sensory endings establishes the driving force for depolarizing, and even excitatory, Cl− currents. The intracellular Cl− concentration can, however, vary considerably between individual DRG neurons. This raises the question, whether the contribution of Cl− currents to signal generation differs between individual afferent neurons, and whether the specific Cl− levels in these neurons are subject to modulation. Based on the hypothesis that modulation of the peripheral Cl− homeostasis is involved in the generation of inflammatory hyperalgesia, we examined the effects of inflammatory mediators on intracellular Cl− concentrations and on the expression levels of Cl− transporters in rat DRG neurons.Results:We developed an in vitro assay for testing how inflammatory mediators influence Cl− concentration and the expression of Cl− transporters. Intact DRGs were...
Item Description:Gesehen am 15.05.2017
Physical Description:Online Resource
ISSN:1744-8069
DOI:10.1186/1744-8069-4-32

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