Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons
Background:Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl− accumulation in sensory endings establishes the driving force for depolarizing, and even excitatory, Cl− currents. The intracellular Cl− concentration can, ho...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 August 2008
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| In: |
Molecular pain
Year: 2008, Jahrgang: 4, Pages: 1-12 |
| ISSN: | 1744-8069 |
| DOI: | 10.1186/1744-8069-4-32 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1744-8069-4-32 Verlag, kostenfrei, Volltext: http://journals.sagepub.com/doi/10.1186/1744-8069-4-32 
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| Verfasserangaben: | Katharina Funk, Anne Woitecki, Christina Franjic-Würtz, Thomas Gensch, Frank Möhrlen and Stephan Frings |
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| 245 | 1 | 0 | |a Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons |c Katharina Funk, Anne Woitecki, Christina Franjic-Würtz, Thomas Gensch, Frank Möhrlen and Stephan Frings |
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| 520 | |a Background:Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl− accumulation in sensory endings establishes the driving force for depolarizing, and even excitatory, Cl− currents. The intracellular Cl− concentration can, however, vary considerably between individual DRG neurons. This raises the question, whether the contribution of Cl− currents to signal generation differs between individual afferent neurons, and whether the specific Cl− levels in these neurons are subject to modulation. Based on the hypothesis that modulation of the peripheral Cl− homeostasis is involved in the generation of inflammatory hyperalgesia, we examined the effects of inflammatory mediators on intracellular Cl− concentrations and on the expression levels of Cl− transporters in rat DRG neurons.Results:We developed an in vitro assay for testing how inflammatory mediators influence Cl− concentration and the expression of Cl− transporters. Intact DRGs were... | ||
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