Monitoring spindle orientation: spindle position checkpoint in charge
Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation. A surveillance mechanism named the spindle position checkpoint (SPOC), monitors the orientation of t...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 December 2010
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| In: |
Cell division
Year: 2010, Volume: 5 |
| ISSN: | 1747-1028 |
| DOI: | 10.1186/1747-1028-5-28 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1747-1028-5-28
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| Author Notes: | Ayse K. Caydasi, Bashar Ibrahim, Gislene Pereira |
| Summary: | Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation. A surveillance mechanism named the spindle position checkpoint (SPOC), monitors the orientation of the mitotic spindle and prevents cells from exiting mitosis when the spindle fails to align along the mother-daughter axis. SPOC is essential for maintenance of ploidy in budding yeast and similar mechanisms might exist in higher eukaryotes to ensure faithful asymmetric cell division. Here, we review the current model of SPOC activation and highlight the importance of protein localization and phosphorylation for SPOC function. |
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| Item Description: | Gesehen am 16.05.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1747-1028 |
| DOI: | 10.1186/1747-1028-5-28 |