Vertebrate-type intron-rich genes in the marine annelid platynereis dumerilii
Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns pr...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 25, 2005
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| In: |
Science
Year: 2005, Volume: 310, Issue: 5752, Pages: 1325-1326 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1119089 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1126/science.1119089 Verlag, Volltext: http://science.sciencemag.org/content/310/5752/1325 
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| Author Notes: | Florian Raible, Kristin Tessmar-Raible, Kazutoyo Osoegawa, Patrick Wincker, Claire Jubin, Guillaume Balavoine, David Ferrier, Vladimir Benes, Pieter de Jong, Jean Weissenbach, Peer Bork, Detlev Arendt |
| Summary: | Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human. Genes resembling intron-rich human genes are found in a marine polychaete, indicating their presence in the bilateral ancestor and their secondary loss in other invertebrates. |
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| Item Description: | Gesehen am 17.05.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1119089 |