Curvature recognition and force generation in phagocytosis

The uptake of particles by actin-powered invagination of the plasma membrane is common to protozoa and to phagocytes involved in the immune response of higher organisms. The question addressed here is how a phagocyte may use geometric cues to optimize force generation for the uptake of a particle. W...

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Bibliographic Details
Main Authors: Clarke, Margaret (Author) , Engel, Ulrike (Author)
Format: Article (Journal)
Language:English
Published: 29 December 2010
In: BMC biology
Year: 2010, Volume: 8
ISSN:1741-7007
DOI:10.1186/1741-7007-8-154
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1741-7007-8-154
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Author Notes:Margaret Clarke, Ulrike Engel, Jennifer Giorgione, Annette Müller-Taubenberger, Jana Prassler, Douwe Veltman, Günther Gerisch
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Summary:The uptake of particles by actin-powered invagination of the plasma membrane is common to protozoa and to phagocytes involved in the immune response of higher organisms. The question addressed here is how a phagocyte may use geometric cues to optimize force generation for the uptake of a particle. We survey mechanisms that enable a phagocyte to remodel actin organization in response to particles of complex shape.
Item Description:Gesehen am 22.05.2017
Physical Description:Online Resource
ISSN:1741-7007
DOI:10.1186/1741-7007-8-154