Distribution of the CCR5-delta32 deletion in Southwest Germany
A 32 base pair deletion in the c-c chemokine receptor gene 5 (CCR5) leads to an inactive protein. Carriers of this deletion must have had a selective advantage because the allelic frequency of the CCR5-delat32 mutation is much higher than expected. Furthermore, there is a decline from North to South...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1. August 2015
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| In: |
Journal of biological and clinical anthropology
Year: 2015, Volume: 72, Issue: 3, Pages: 303-309 |
| ISSN: | 2363-7099 |
| Online Access: |
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| Author Notes: | Gero Hütter, Christian Blüthgen, Susanne Elvers-Hornung, Harald Klüter, Peter Bugert |
| Summary: | A 32 base pair deletion in the c-c chemokine receptor gene 5 (CCR5) leads to an inactive protein. Carriers of this deletion must have had a selective advantage because the allelic frequency of the CCR5-delat32 mutation is much higher than expected. Furthermore, there is a decline from North to South Europe. For Germany there are just very few cross-sectional surveys available. Here we investigated a large number of healthy blood donors from Northern Baden-Wuerttemberg. We observed an allelic frequency of 9.21 % of the CCR5-delta32 deletion. The distribution did not follow the Hardy-Weinberg equilibrium suggesting that homozygous carriers of the deletion were overrepresented in this random sample. |
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| Item Description: | Gesehen am 23.05.2017 |
| Physical Description: | Online Resource |
| ISSN: | 2363-7099 |