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Hedgehog signaling regulates segment formation in the Annelid platynereis

Annelids and arthropods share a similar segmented organization of the body whose evolutionary origin remains unclear. The Hedgehog signaling pathway, prominent in arthropod embryonic segment patterning, has not been shown to have a similar function outside arthropods. We show that the ligand Hedgeho...

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Bibliographic Details
Main Authors: Dray, Nicolas (Author) , Tessmar-Raible, Kristin (Author) , Christodoulou, Foteini (Author) , Snyman, Heidi (Author) , Arendt, Detlev (Author)
Format: Article (Journal)
Language:English
Published: 16 Jul 2010
In: Science
Year: 2010, Volume: 329, Issue: 5989, Pages: 339-342
ISSN:1095-9203
DOI:10.1126/science.1188913
Online Access:Verlag, Volltext: http://dx.doi.org/10.1126/science.1188913
Verlag, Volltext: http://science.sciencemag.org/content/329/5989/339
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Author Notes:Nicolas Dray, Kristin Tessmar-Raible, Martine Le Gouar, Laura Vibert, Foteini Christodoulou, Katharina Schipany, Aurélien Guillou, Juliane Zantke, Heidi Snyman, Julien Béhague, Michel Vervoort, Detlev Arendt, Guillaume Balavoine
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Summary:Annelids and arthropods share a similar segmented organization of the body whose evolutionary origin remains unclear. The Hedgehog signaling pathway, prominent in arthropod embryonic segment patterning, has not been shown to have a similar function outside arthropods. We show that the ligand Hedgehog, the receptor Patched, and the transcription factor Gli are all expressed in striped patterns before the morphological appearance of segments in the annelid Platynereis dumerilii. Treatments with small molecules antagonistic to Hedgehog signaling disrupt segment formation. Platynereis Hedgehog is not necessary to establish early segment patterns but is required to maintain them. The molecular similarity of segment patterning functions of the Hedgehog pathway in an annelid and in arthropods supports a common origin of segmentation in protostomes. The processes that pattern body segmentation in annelids and arthropods both require the same signaling mechanism.
Item Description:Gesehen am 24.05.2014
Physical Description:Online Resource
ISSN:1095-9203
DOI:10.1126/science.1188913

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