MTHFD1 controls DNA methylation in Arabidopsis
DNA methylation contributes to transcriptional silencing. Here, Groth et al.show that mutant plants defective in MTHFD1, an enzyme involved in folate metabolism, have a DNA hypomethylation phenotype highlighting the link between one-carbon metabolism and DNA methylation, which is mediated by SAM as...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 June 2016
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| In: |
Nature Communications
Year: 2016, Volume: 7 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms11640 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/ncomms11640 Verlag, Volltext: http://www.nature.com/ncomms/2016/160613/ncomms11640/full/ncomms11640.html 
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| Author Notes: | Martin Groth, Guillaume Moissiard, Markus Wirtz, Haifeng Wang, Carolina Garcia-Salinas, Perla A. Ramos-Parra, Sylvain Bischof, Suhua Feng, Shawn J. Cokus, Amala John, Danielle C. Smith, Jixian Zhai, Christopher J. Hale, Jeff A. Long, Ruediger Hell, Rocío I. Díaz de la Garza & Steven E. Jacobsen |
| Summary: | DNA methylation contributes to transcriptional silencing. Here, Groth et al.show that mutant plants defective in MTHFD1, an enzyme involved in folate metabolism, have a DNA hypomethylation phenotype highlighting the link between one-carbon metabolism and DNA methylation, which is mediated by SAM as a common methyl donor. |
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| Item Description: | Gesehen am 29.05.2017 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms11640 |