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The transforming growth factor-βs: structure, signaling, and roles in nervous system development and functions

Abstract: Transforming growth factor-βs (TGF-βs) are amongthe most widespread and versatile cytokines. Here, we first provide a briefoverview of their molecular biology, biochemistry, and signaling. We thenreview distribution and functions of the three mammalian TGF-β isoforms,β1, β2, and β3, and th...

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Bibliographic Details
Main Authors: Böttner, Martina (Author) , Krieglstein, Kerstin (Author) , Unsicker, Klaus (Author)
Format: Article (Journal)
Language:English
Published: December 2000
In: Journal of neurochemistry
Year: 2000, Volume: 75, Issue: 6, Pages: 2227-2240
ISSN:1471-4159
DOI:10.1046/j.1471-4159.2000.0752227.x
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1046/j.1471-4159.2000.0752227.x
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2000.0752227.x/abstract
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Author Notes:Martina Böttner, Kerstin Krieglstein, and Klaus Unsicker
Description
Summary:Abstract: Transforming growth factor-βs (TGF-βs) are amongthe most widespread and versatile cytokines. Here, we first provide a briefoverview of their molecular biology, biochemistry, and signaling. We thenreview distribution and functions of the three mammalian TGF-β isoforms,β1, β2, and β3, and their receptors in the developing and adultnervous system. Roles of TGF-βs in the regulation of radial glia,astroglia, oligodendroglia, and microglia are addressed. Finally, we reviewthe current state of knowledge concerning the roles of TGF-βs incontrolling neuronal performances, including the regulation of proliferationof neuronal precursors, survival/death decisions, and neuronaldifferentiation.
Item Description:Gesehen am 02.06.2017
Physical Description:Online Resource
ISSN:1471-4159
DOI:10.1046/j.1471-4159.2000.0752227.x

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