The transforming growth factor-βs: structure, signaling, and roles in nervous system development and functions
Abstract: Transforming growth factor-βs (TGF-βs) are amongthe most widespread and versatile cytokines. Here, we first provide a briefoverview of their molecular biology, biochemistry, and signaling. We thenreview distribution and functions of the three mammalian TGF-β isoforms,β1, β2, and β3, and th...
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| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2000
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| In: |
Journal of neurochemistry
Year: 2000, Jahrgang: 75, Heft: 6, Pages: 2227-2240 |
| ISSN: | 1471-4159 |
| DOI: | 10.1046/j.1471-4159.2000.0752227.x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1046/j.1471-4159.2000.0752227.x Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2000.0752227.x/abstract |
| Verfasserangaben: | Martina Böttner, Kerstin Krieglstein, and Klaus Unsicker |
MARC
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| 520 | |a Abstract: Transforming growth factor-βs (TGF-βs) are amongthe most widespread and versatile cytokines. Here, we first provide a briefoverview of their molecular biology, biochemistry, and signaling. We thenreview distribution and functions of the three mammalian TGF-β isoforms,β1, β2, and β3, and their receptors in the developing and adultnervous system. Roles of TGF-βs in the regulation of radial glia,astroglia, oligodendroglia, and microglia are addressed. Finally, we reviewthe current state of knowledge concerning the roles of TGF-βs incontrolling neuronal performances, including the regulation of proliferationof neuronal precursors, survival/death decisions, and neuronaldifferentiation. | ||
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